RPA3 - replication protein A3 Gene

Homo sapiens

Also known as REPA3; RP-A p14

Gene ID: 6119 | Gene type: protein coding

About RPA3

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:7,636,518-7,718,607 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 9.0), bone marrow (RPKM 7.1) and 25 other tissues.

Summary

Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]

RPA3 Products(1)

mRNA	Protein	Name
NM_002947.5	NP_002938.1	replication protein A 14 kDa subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables damaged DNA binding	IDA IDA: Inferred from direct assay	7700386	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2159011	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	19010961	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA repair	IDA IDA: Inferred from direct assay	20545304	GOA
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	9430682	GOA
involved in base-excision repair	IDA IDA: Inferred from direct assay	9765279	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	17765923	GOA
involved in mismatch repair	IMP IMP: Inferred from mutant phenotype	9430682	GOA
involved in nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	9430682	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA replication factor A complex	IDA IDA: Inferred from direct assay	11927569	GOA
part of DNA replication factor A complex	IPI IPI: Inferred from physical interaction	7760808	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPA3 Protein Structure

Rep_fac-A_3

0
100
121 a.a.

Protein Preferred Names

Protein Names

replication protein A 14 kDa subunit

RF-A protein 3

RPA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPA3	P35244	RPA4	Homo sapiens	Q13156	Y2H	7760808
Intra	RPA3	P35244	RPA1	Homo sapiens	P27694	TAP	24126761
Intra	RPA3	P35244	RPA2	Homo sapiens	P15927	Pull Down	10982866
Intra	RPA3	P35244	RPA2	Homo sapiens	P15927	X-Ray Diffraction	10449415
Intra	RPA3	P35244	RPA2	Homo sapiens	P15927	Y2H	15965237
Intra	RPA3	P35244	RPA2	Homo sapiens	P15927	Y2H	10982866
Intra	RPA3	P35244	RPA2	Homo sapiens	P15927	TAP	24126761
Intra	RPA3	P35244	RAD52	Homo sapiens	P43351	TAP	24126761

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rheumatoid Arthritis Interstitial Lung Disease

Rheumatoid Lung

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12144	RPA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPA3	VGNC	VGNC:34096
Rattus norvegicus	RPA3	RGD	RGD:1306810
Mus musculus	RPA3	MGD	MGI:1915490
Felis catus	RPA3	VGNC	VGNC:80672
Canis familiaris	RPA3	VGNC	VGNC:45704

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