2. Gene
  3. RPL3 - ribosomal protein L3 Gene

RPL3 - ribosomal protein L3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as L3; ASC-1; TARBP-B

Gene ID: 6122 | Gene type: protein coding

About RPL3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,312,882-39,319,623 (from NCBI)

This gene has 18 transcripts (splice variants), 229 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 2560.0), skin (RPKM 1107.2) and 25 other tissues.

Summary

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL3 Products(2)

mRNA Protein Name
NM_000967.4 NP_000958.1 60S ribosomal protein L3 isoform a
NM_001033853.2 NP_001029025.1 60S ribosomal protein L3 isoform b
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23349634 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Cellular Component GO Annotation Evidence Reference Source
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
32669547 GOA
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
32669547 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
16963496 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23349634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL3 Protein Structure

Ribosomal_L3

Ribosomal_L3: Ribosomal protein L3 (50 - 348)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L3

HIV-1 TAR RNA-binding protein B

RPL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RPL3 P39023 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
RPL3 P39023 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
RPL3 P39023 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome

Shwachman Syndrome

Shwachman-Bodian-Diamond Syndrome

Sds

Pancreatic Insufficiency And Bone Marrow Dysfunction

Shwachman-Bodian Syndrome

SDS1

Lipomatosis Of Pancreas, Congenital

Congenital Lipomatosis Of Pancreas

Shwachman-Diamond Type Metaphyseal Dysplasia

Metaphyseal Chondrodysplasia, Shwachman Type

Shwachman-Diamond-Oski Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12184 RPL3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12198 RPL3L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RPL3 VGNC VGNC:101451
Rattus norvegicus RPL3 RGD RGD:735105
Felis catus RPL3 VGNC VGNC:97609
Mus musculus RPL3 MGD MGI:1351605