RPL41 - ribosomal protein L41 Gene

Homo sapiens

Also known as L41

Gene ID: 6171 | Gene type: protein coding

About RPL41

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,116,633-56,117,967 (from NCBI)

This gene has 6 transcripts (splice variants) and 4 orthologues. Ubiquitous expression in ovary (RPKM 1672.2), colon (RPKM 1110.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA Topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL41 Products(2)

mRNA	Protein	Name
NM_001035267.2	NP_001030344.1	60S ribosomal protein L41
NM_021104.2	NP_066927.1	60S ribosomal protein L41

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	25957688	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL41 Protein Structure

Ribosomal_L41

0
25 a.a.

Protein Preferred Names

Protein Names

60S ribosomal protein L41

HG12 protein

RPL41 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPL41	P62945	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	RPL41	P62945	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	RPL41	P62945	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12200	RPL41 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL41	RGD	RGD:621210

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