RPLP0 - ribosomal protein lateral stalk subunit P0 Gene

Homo sapiens

Also known as P0; LP0; L10E; RPP0; PRLP0

Gene ID: 6175 | Gene type: protein coding

About RPLP0

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,196,699-120,201,111 (from NCBI)

This gene has 27 transcripts (splice variants), 181 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 1127.2), bone marrow (RPKM 877.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPLP0 Products(2)

mRNA	Protein	Name
NM_001002.4	NP_000993.1	60S acidic ribosomal protein P0
NM_053275.4	NP_444505.1	60S acidic ribosomal protein P0

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15121898	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	3323886	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19188445	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	3323886	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19188445	GOA
is active in postsynapse	EXP EXP: Inferred from Experiment	23071613	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	23071613	GOA
is active in postsynaptic density	EXP EXP: Inferred from Experiment	21170055	GOA
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21170055	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPLP0 Protein Structure

Ribosomal_L10

Ribosomal_60s

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

60S acidic ribosomal protein P0

60S ribosomal protein L10E

RPLP0 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPLP0	P05388	STAU1	Homo sapiens	O95793	CoIP	15303970
Intra	RPLP0	P05388	STAU1	Homo sapiens	O95793	Anti Tag CoIP	33961781
Intra	RPLP0	P05388	STAU1	Homo sapiens	O95793	Affinity Chrom	15303970
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Anti Tag CoIP	33961781
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Anti Tag CoIP	28514442
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chagas Disease

American Trypanosomiasis	Chagas' Disease
Chagas' Disease With Digestive System Involvement	Chagas' Disease With Nervous System Involvement
Chagas' Disease With Other Organ Involvement	Infection Due To Trypanosoma Cruzi
South American Trypanosomiasis	Chronic Chagas Disease With Digestive System Involvement

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12207	RPLP0 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPLP0	MGD	MGI:1927636
Felis catus	RPLP0	VGNC	VGNC:82551
Bos taurus	RPLP0	VGNC	VGNC:107262
Rattus norvegicus	RPLP0	RGD	RGD:621247

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