1. Gene
  2. STAU1 - staufen double-stranded RNA binding protein 1 Gene

STAU1 - staufen double-stranded RNA binding protein 1 Gene

Homo sapiens

Also known as STAU; PPP1R150

Gene ID: 6780 | Gene type: protein coding

About STAU1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,113,339-49,219,295 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 14 paralogues. Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues.

Summary

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]

STAU1 Products(14)

mRNA Protein Name
NM_001037328.3 NP_001032405.1 double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319134.2 NP_001306063.1 double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319135.2 NP_001306064.1 double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322927.2 NP_001309856.1 double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001322928.2 NP_001309857.1 double-stranded RNA-binding protein Staufen homolog 1 isoform d
NM_001322929.2 NP_001309858.1 double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322930.2 NP_001309859.1 double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322931.2 NP_001309860.1 double-stranded RNA-binding protein Staufen homolog 1 isoform e
NM_001322932.2 NP_001309861.1 double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_001322933.2 NP_001309862.1 double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_004602.4 NP_004593.2 double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017452.4 NP_059346.2 double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017453.4 NP_059347.2 double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_017454.4 NP_059348.2 double-stranded RNA-binding protein Staufen homolog 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15121898 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation by virus of viral protein levels in host cell IMP
IMP: Inferred from mutant phenotype
23907398 GOA
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
23907398 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell body IDA
IDA: Inferred from direct assay
15121898 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19029303 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
15121898 GOA
located in dendrite IDA
IDA: Inferred from direct assay
15121898 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23907398 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22978549 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAU1 Protein Structure

dsrm

dsrm: Double-stranded RNA binding motif (110 - 160)

dsrm

dsrm: Double-stranded RNA binding motif (186 - 249)

dsrm

dsrm: Double-stranded RNA binding motif (287 - 352)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
Protein Preferred Names Protein Names

double-stranded RNA-binding protein Staufen homolog 1

protein phosphatase 1, regulatory subunit 150

STAU1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STAU1 O95793 ADARB1 Homo sapiens P78563-4
Validated Y2H
32296183
Intra
STAU1 O95793 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra
STAU1 O95793 LONRF1 Homo sapiens Q17RB8
Y2H Array
25416956
Intra
STAU1 O95793 ZMAT3 Homo sapiens Q9HA38
Y2H Array
25416956
Intra
STAU1 O95793 NXT1 Homo sapiens Q9UKK6
Y2H Prey Pooling
25416956
Intra
STAU1 O95793 NXT1 Homo sapiens Q9UKK6
Validated Y2H
32296183
Intra
STAU1 O95793 NXT1 Homo sapiens Q9UKK6
Y2H Array
25416956
Cross
STAU1 O95793 Klf4 Mus musculus Q60793
Anti Tag CoIP
29374155
Intra
STAU1 O95793 RPLP0 Homo sapiens P05388
Affinity Chrom
15303970
Intra
STAU1 O95793 RPLP0 Homo sapiens P05388
TAP
15121898
Intra
STAU1 O95793 RPL7A Homo sapiens P62424
Affinity Chrom
15303970
Intra
STAU1 O95793 RPL7A Homo sapiens P62424
Anti Tag CoIP
33961781
Intra
STAU1 O95793 UPF1 Homo sapiens Q92900
Anti Tag CoIP
23722113
Intra
STAU1 O95793 UPF1 Homo sapiens Q92900
Complementation
15680326
Intra
STAU1 O95793 UPF1 Homo sapiens Q92900
Far-WB
15680326
Intra
STAU1 O95793 UPF1 Homo sapiens Q92900
Pull Down
15680326
Intra
STAU1 O95793 GLRX3 Homo sapiens O76003
Y2H Array
25416956
Intra
STAU1 O95793 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Intra
STAU1 O95793 GLRX3 Homo sapiens O76003
Validated Y2H
25416956
Intra
STAU1 O95793 STRBP Homo sapiens Q96SI9
Validated Y2H
32296183
Cross
STAU1 O95793 NS Influenza A virus P03496
Y2H Array
23853584
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Philophthalmiasis
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1

Autosomal Dominant Non-Syndromic Intellectual Disability 1

Mental Retardation, Autosomal Dominant 1

Autosomal Dominant Intellectual Developmental Disorder 1

Meckel Diverticulum

Meckel'S Diverticulum

Persistent Vitelline Duct

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus STAU1 MGD MGI:1338864
Canis familiaris STAU1 VGNC VGNC:46893
Macaca mulatta STAU1 VGNC VGNC:77909
Rattus norvegicus STAU1 RGD RGD:621778
Bos taurus STAU1 VGNC VGNC:35375
Felis catus STAU1 VGNC VGNC:65764