RPS4X - ribosomal protein S4 X-linked Gene

Homo sapiens

Also known as S4; CCG2; RPS4; SCAR; SCR10; DXS306

Gene ID: 6191 | Gene type: protein coding

About RPS4X

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,272,042-72,277,248 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 1675.7), lymph node (RPKM 944.2) and 25 other tissues.

Summary

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS4X Products(1)

mRNA	Protein	Name
NM_001007.5	NP_000998.1	40S ribosomal protein S4, X isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24965446	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	8358435	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	1795030	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	1795030	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in translation	IMP IMP: Inferred from mutant phenotype	8358435	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA
located in ribosome	IDA IDA: Inferred from direct assay	8139551	GOA
part of small ribosomal subunit	IDA IDA: Inferred from direct assay	8139551	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS4X Protein Structure

RS4NT

Ribosomal_S4e

KOW

0
100
200
263 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S4, X isoform

cell cycle gene 2

RPS4X Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS4X	P62701	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	RPS4X	P62701	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	RPS4X	P62701	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	RPS4X	P62701	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	RPS4X	P62701	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	RPS4X	P62701	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	RPS4X	P62701	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	RPS4X	P62701	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	RPS4X	P62701	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	RPS4X	P62701	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	RPS4X	P62701	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RPS4X	P62701	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RPS4X	P62701	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	RPS4X	P62701	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	RPS4X	P62701	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	RPS4X	P62701	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RPS4X	P62701	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RPS4X	P62701	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RPS4X	P62701	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	RPS4X	P62701	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	RPS4X	P62701	CCK	Homo sapiens	P06307	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Turner Syndrome

Monosomy X	Gonadal Dysgenesis Turner Type
Ullrich-Turner Syndrome	Bonnevie-Ullrich Syndrome
Karyotype 45, X	Genital Dwarfism, Turner Type
Gonadal Dysgenesis	45,X
Turner'S Syndrome	Gonadal Dysgenesis - Turner
Monosomy X Syndrome	Xo Syndrome
Genital Dwarfism	45, X Syndrome
Bonnevie-Ulrich Syndrome	Chromosome X Monosomy X
Schereshevkii Turner Syndrome	Turner Varny Syndrome
Ts	45,X Syndrome
45,X/46,Xx Syndrome	Turners Syndrome
Gonadal Dysgenesis, 45,X	X0 Syndrome

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12244	RPS4X Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS4X	MGD	MGI:98158
Rattus norvegicus	RPS4X	RGD	RGD:2324318

Name
Email *

	Sorry, but the email address you supplied was invalid.