RPS15A - ribosomal protein S15a Gene

Homo sapiens

Also known as S15a; DBA20

Gene ID: 6210 | Gene type: protein coding

About RPS15A

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:18,781,295-18,790,334 (from NCBI)

This gene has 13 transcripts (splice variants), 129 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 1052.3), bone marrow (RPKM 811.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS15A Products(2)

mRNA	Protein	Name
NM_001019.5	NP_001010.2	40S ribosomal protein S15a
NM_001030009.2	NP_001025180.1	40S ribosomal protein S15a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24965446	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell cycle	IDA IDA: Inferred from direct assay	15108328	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15108328	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	15108328	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15108328	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS15A Protein Structure

Ribosomal_S8

0
100
130 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S15a

small ribosomal subunit protein uS8

RPS15A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS15A	P62244	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	RPS15A	P62244	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	RPS15A	P62244	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	RPS15A	P62244	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RPS15A	P62244	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RPS15A	P62244	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	RPS15A	P62244	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	RPS15A	P62244	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	RPS15A	P62244	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	RPS15A	P62244	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	RPS15A	P62244	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	RPS15A	P62244	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	RPS15A	P62244	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	RPS15A	P62244	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	RPS15A	P62244	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	RPS15A	P62244	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	RPS15A	P62244	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	RPS15A	P62244	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	RPS15A	P62244	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RPS15A	P62244	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RPS15A	P62244	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 20

DBA20

Rps15a-Related Diamond-Blackfan Anemia

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12226	RPS15A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPS15A	RGD	RGD:619939
Mus musculus	RPS15A	MGD	MGI:2389091

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