2. Gene
  3. RPS25 - ribosomal protein S25 Gene

RPS25 - ribosomal protein S25 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as S25

Gene ID: 6230 | Gene type: protein coding

About RPS25

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,015,717-119,018,343 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 201 orthologues. Ubiquitous expression in ovary (RPKM 1368.6), lymph node (RPKM 772.3) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS25 Products(1)

mRNA Protein Name
NM_001028.3 NP_001019.1 40S ribosomal protein S25
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22720776 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
enables structural constituent of ribosome IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Biological Process GO Annotation Evidence Reference Source
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
18697920 GOA
involved in ribosomal small subunit biogenesis IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
10050887 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22720776 GOA
is active in postsynaptic density EXP
EXP: Inferred from Experiment
21170055 GOA
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21170055 GOA
located in ribosome IDA
IDA: Inferred from direct assay
1748303 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS25 Protein Structure

Ribosomal_S25

Ribosomal_S25: S25 ribosomal protein (1 - 113)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

40S ribosomal protein S25

small ribosomal subunit protein eS25

RPS25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RPS25 P62851 ZBTB14 Homo sapiens O43829
Y2H Array
32296183
Intra
RPS25 P62851 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
32296183
Intra
RPS25 P62851 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
RPS25 P62851 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
RPS25 P62851 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
Intra
RPS25 P62851 NKAPD1 Homo sapiens Q6ZUT1
Validated Y2H
32296183
Intra
RPS25 P62851 THAP1 Homo sapiens Q9NVV9
Validated Y2H
25416956
Intra
RPS25 P62851 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
RPS25 P62851 STAC3 Homo sapiens Q96MF2
Validated Y2H
32296183
Intra
RPS25 P62851 STAC3 Homo sapiens Q96MF2
Y2H Array
32296183
Intra
RPS25 P62851 STAC3 Homo sapiens Q96MF2
Y2H Prey Pooling
32296183
Intra
RPS25 P62851 TSPYL2 Homo sapiens Q9H2G4
Validated Y2H
32296183
Intra
RPS25 P62851 TSPYL2 Homo sapiens Q9H2G4
Y2H Prey Pooling
32296183
Intra
RPS25 P62851 TSPYL2 Homo sapiens Q9H2G4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 5q Deletion Syndrome

5q- Syndrome

Mar

Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality

Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic

5q Deletion Syndrome

5q Minus Syndrome

Refractory Macrocytic Anemia Due To 5q Deletion

Myelodysplastic Syndrome With Isolated Del

Macrocytic Anemia, Refractory, Due To 5q Deletion

5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion

5q Syndrome

Chromosome 5q Deletion

Myelodysplastic Syndrome With 5q Deletion

Myelodysplastic Syndrome With 5q Deletion Syndrome

Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic

5q-Syndrome

Chromosome 5, Trisomy 5q

Loss Of Chromosome 5q

5 Q- Syndrome
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12236 RPS25 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RPS25 RGD RGD:621043
Mus musculus RPS25 MGD MGI:1922867