ZBTB14 - zinc finger and BTB domain containing 14 Gene

Homo sapiens

Also known as ZF5; ZFP-5; ZFP161; ZNF478; ZFP-161

Gene ID: 7541 | Gene type: protein coding

About ZBTB14

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:5,289,022-5,297,053 (from NCBI)

This gene has 9 transcripts (splice variants), 192 orthologues and 28 paralogues. Ubiquitous expression in lymph node (RPKM 9.0), appendix (RPKM 6.6) and 25 other tissues.

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in aggresome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB14 Products(4)

mRNA	Protein	Name
NM_001143823.3	NP_001137295.1	zinc finger and BTB domain-containing protein 14
NM_001243702.2	NP_001230631.1	zinc finger and BTB domain-containing protein 14
NM_001243704.2	NP_001230633.1	zinc finger and BTB domain-containing protein 14
NM_003409.5	NP_003400.2	zinc finger and BTB domain-containing protein 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17714511	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15629158	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17714511	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17714511	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17714511	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15629158	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB14 Protein Structure

BTB

zf-H2C2_2

0
100
200
300
400
449 a.a.

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 14

ZFP161 zinc finger protein

ZBTB14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZBTB14	O43829	rnps1	Homo sapiens	D3DU92	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	rnps1	Homo sapiens	D3DU92	Validated Y2H	25416956
Intra	ZBTB14	O43829	SYT16	Homo sapiens	Q17RD7	Validated Y2H	25416956
Intra	ZBTB14	O43829	SYT16	Homo sapiens	Q17RD7	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	BAZ2B	Homo sapiens	Q9UIF8-2	Y2H Array	25416956
Intra	ZBTB14	O43829	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	ZBTB14	O43829	PNKP	Homo sapiens	Q96T60	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	SNRPB2	Homo sapiens	P08579	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	SNRPB2	Homo sapiens	P08579	Validated Y2H	32296183
Intra	ZBTB14	O43829	SNRPB2	Homo sapiens	P08579	Validated Y2H	25416956
Intra	ZBTB14	O43829	C2orf68	Homo sapiens	Q2NKX9	Validated Y2H	32296183
Intra	ZBTB14	O43829	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	ZBTB14	O43829	RNASEH2B	Homo sapiens	Q8N451	Validated Y2H	32296183
Intra	ZBTB14	O43829	CDK16	Homo sapiens	Q00536-3	Validated Y2H	32296183
Intra	ZBTB14	O43829	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	ZBTB14	O43829	q96bh6_human	Homo sapiens	Q96BH6	Validated Y2H	32814053
Intra	ZBTB14	O43829	q96bh6_human	Homo sapiens	Q96BH6	Y2H Array	32814053
Intra	ZBTB14	O43829	q96bh6_human	Homo sapiens	Q96BH6	Y2H Pooling	32814053
Intra	ZBTB14	O43829	INTS3	Homo sapiens	Q68E01	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
Intra	ZBTB14	O43829	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ZBTB14	O43829	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ZBTB14	O43829	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ZBTB14	O43829	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	ZBTB14	O43829	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	ZBTB14	O43829	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	ZBTB14	O43829	DDX6	Homo sapiens	P26196	Validated Y2H	32296183
Intra	ZBTB14	O43829	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	ZBTB14	O43829	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	ZBTB14	O43829	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	ZBTB14	O43829	RPS25	Homo sapiens	P62851	Validated Y2H	32296183
Intra	ZBTB14	O43829	RPS7	Homo sapiens	P62081	Y2H Array	31515488
Intra	ZBTB14	O43829	RPS7	Homo sapiens	P62081	Validated Y2H	25416956
Intra	ZBTB14	O43829	RPS7	Homo sapiens	P62081	Y2H Array	25416956
Intra	ZBTB14	O43829	RPS7	Homo sapiens	P62081	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	ATP5PO	Homo sapiens	P48047	Y2H Array	25416956
Intra	ZBTB14	O43829	ATP5PO	Homo sapiens	P48047	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	ATP5PO	Homo sapiens	P48047	Validated Y2H	25416956
Intra	ZBTB14	O43829	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	ZBTB14	O43829	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	ZBTB14	O43829	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	ZBTB14	O43829	RPL9	Homo sapiens	P32969	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	POLR2L	Homo sapiens	P62875	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	POLR2L	Homo sapiens	P62875	Validated Y2H	25416956
Intra	ZBTB14	O43829	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	25416956
Intra	ZBTB14	O43829	KAT5	Homo sapiens	Q92993	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	ZBTB14	O43829	MORF4L2	Homo sapiens	Q15014	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	MORF4L2	Homo sapiens	Q15014	Validated Y2H	25416956
Intra	ZBTB14	O43829	CYCS	Homo sapiens	P99999	Y2H Pooling	32814053
Intra	ZBTB14	O43829	CYCS	Homo sapiens	P99999	Validated Y2H	32814053
Intra	ZBTB14	O43829	CYCS	Homo sapiens	P99999	Y2H Array	32814053
Intra	ZBTB14	O43829	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	ZBTB14	O43829	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	ZBTB14	O43829	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	ZBTB14	O43829	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	ZBTB14	O43829	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
Intra	ZBTB14	O43829	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	32296183
Intra	ZBTB14	O43829	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	25416956
Intra	ZBTB14	O43829	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Array	25416956
Intra	ZBTB14	O43829	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	EPM2AIP1	Homo sapiens	Q7L775	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	32296183
Intra	ZBTB14	O43829	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
Intra	ZBTB14	O43829	MAD2L1BP	Homo sapiens	Q15013	Validated Y2H	32296183
Intra	ZBTB14	O43829	MAD2L1BP	Homo sapiens	Q15013	Y2H Array	25416956
Intra	ZBTB14	O43829	MAD2L1BP	Homo sapiens	Q15013	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	ZBTB14	O43829	CBX8	Homo sapiens	Q9HC52	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	CBX8	Homo sapiens	Q9HC52	Y2H Array	25416956
Intra	ZBTB14	O43829	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
Intra	ZBTB14	O43829	PIN1	Homo sapiens	Q13526	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	CAPN6	Homo sapiens	Q9Y6Q1	Validated Y2H	32296183
Intra	ZBTB14	O43829	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	ZBTB14	O43829	CDK16	Homo sapiens	Q00536	Y2H Array	25416956
Intra	ZBTB14	O43829	CDK16	Homo sapiens	Q00536	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	ZBTB14	O43829	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	ZBTB14	O43829	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	ZBTB14	O43829	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956
Intra	ZBTB14	O43829	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	29892012
Intra	ZBTB14	O43829	CEP19	Homo sapiens	Q96LK0	Validated Y2H	32296183
Intra	ZBTB14	O43829	CEP19	Homo sapiens	Q96LK0	Y2H Array	25416956
Intra	ZBTB14	O43829	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	25416956
Intra	ZBTB14	O43829	NAA10	Homo sapiens	P41227	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	NAA10	Homo sapiens	P41227	Validated Y2H	32296183
Intra	ZBTB14	O43829	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
Intra	ZBTB14	O43829	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ZBTB14	O43829	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ZBTB14	O43829	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	ZBTB14	O43829	EIF1AD	Homo sapiens	Q8N9N8	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	EAF1	Homo sapiens	Q96JC9	Validated Y2H	25416956
Intra	ZBTB14	O43829	EAF1	Homo sapiens	Q96JC9	Y2H Array	25416956
Intra	ZBTB14	O43829	TSTD2	Homo sapiens	Q5T7W7	Validated Y2H	32296183
Intra	ZBTB14	O43829	TCEANC	Homo sapiens	Q8N8B7	Y2H Prey Pooling	25416956
Intra	ZBTB14	O43829	TCEANC	Homo sapiens	Q8N8B7	Validated Y2H	25416956
Intra	ZBTB14	O43829	TCEANC	Homo sapiens	Q8N8B7	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Holoprosencephaly 4

HPE4	Holoprosencephaly-4
Holoprosencephaly, Type 4

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15963	ZBTB14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZBTB14	VGNC	VGNC:67162
Rattus norvegicus	ZBTB14	RGD	RGD:628712
Bos taurus	ZBTB14	VGNC	VGNC:37061
Canis familiaris	ZBTB14	VGNC	VGNC:48523
Macaca mulatta	ZBTB14	VGNC	VGNC:78823
Mus musculus	ZBTB14	MGD	MGI:1195345

Name
Email *

	Sorry, but the email address you supplied was invalid.