RSU1 - Ras suppressor protein 1 Gene

Homo sapiens

Also known as RSP-1

Gene ID: 6251 | Gene type: protein coding

About RSU1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:16,590,611-16,817,424 (from NCBI)

This gene has 5 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues.

Summary

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]

RSU1 Products(2)

mRNA	Protein	Name
NM_012425.4	NP_036557.1	ras suppressor protein 1 isoform 1
NM_152724.3	NP_689937.2	ras suppressor protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20926685	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	20926685	GOA
NOT involved in regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	20926685	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	20926685	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RSU1 Protein Structure

LRR_8

LRR_1

LRR_4

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

ras suppressor protein 1

rsu-1

Related Diseases

Diseases

Alias

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12313	RSU1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RSU1	VGNC	VGNC:97822
Bos taurus	RSU1	VGNC	VGNC:57022
Felis catus	RSU1	VGNC	VGNC:97615
Canis familiaris	RSU1	VGNC	VGNC:52921
Rattus norvegicus	RSU1	RGD	RGD:1591781
Mus musculus	RSU1	MGD	MGI:103040

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