LIMS1 - LIM zinc finger domain containing 1 Gene

Homo sapiens

Also known as PINCH; PINCH1; PINCH-1

Gene ID: 3987 | Gene type: protein coding

About LIMS1

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,533,671-108,687,246 (from NCBI)

This gene has 23 transcripts (splice variants), 30 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 18.5), adrenal (RPKM 16.0) and 25 other tissues.

Summary

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in Integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

LIMS1 Products(16)

mRNA	Protein	Name
NM_001193482.2	NP_001180411.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform c
NM_001193483.3	NP_001180412.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform d
NM_001193484.2	NP_001180413.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform e
NM_001193485.3	NP_001180414.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform a
NM_001193488.2	NP_001180417.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371494.1	NP_001358423.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform f
NM_001371495.1	NP_001358424.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform g
NM_001371496.1	NP_001358425.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform h
NM_001371497.1	NP_001358426.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform i
NM_001371498.1	NP_001358427.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371499.1	NP_001358428.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform j
NM_001371500.1	NP_001358429.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform k
NM_001394896.1	NP_001381825.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform l
NM_001394897.1	NP_001381826.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform m
NM_001394898.1	NP_001381827.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform n
NM_004987.6	NP_004978.2	LIM and senescent cell antigen-like-containing domain protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10574708	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20926685	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19074270	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	21390327	GOA
NOT involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21390327	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21343177	GOA
involved in positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	20926685	GOA
NOT involved in regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21343177	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IMP IMP: Inferred from mutant phenotype	20926685	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	19117955	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	20926685	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21390327	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMS1 Protein Structure

LIM

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

LIM and senescent cell antigen-like-containing domain protein 1

LIM and senescent cell antigen-like domains 1

LIMS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LIMS1	P48059	RSU1	Homo sapiens	Q15404	Y2H Array	25416956
Intra	LIMS1	P48059	RSU1	Homo sapiens	Q15404	Anti Tag CoIP	33961781
Intra	LIMS1	P48059	RSU1	Homo sapiens	Q15404	Y2H Array	29892012
Intra	LIMS1	P48059	RSU1	Homo sapiens	Q15404	Y2H Fragment Pooling	23414517
Cross	LIMS1	P48059	Hoxa1	Mus musculus	P09022	Y2H	23088713
Cross	LIMS1	P48059	Ilk	Mus musculus	O55222	ELISA	10574708
Cross	LIMS1	P48059	Ilk	Mus musculus	O55222	Anti Tag CoIP	11331308
Intra	LIMS1	P48059	NCK2	Homo sapiens	O43639	NMR	15721255
Intra	LIMS1	P48059	NCK2	Homo sapiens	O43639	ELISA	10574708
Intra	LIMS1	P48059	ILK	Homo sapiens	Q13418	Anti Tag CoIP	33961781
Intra	LIMS1	P48059	ILK	Homo sapiens	Q13418	Anti Tag CoIP	28514442
Intra	LIMS1	P48059	ILK	Homo sapiens	Q13418	MAPPIT	25416956
Intra	LIMS1	P48059	ILK	Homo sapiens	Q13418	Y2H Fragment Pooling	23414517
Intra	LIMS1	P48059	ILK	Homo sapiens	Q13418	BiFC	23877428
Intra	LIMS1	P48059	ILK	Homo sapiens	Q13418	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 3q13.31 Deletion Syndrome

3q13 Microdeletion Syndrome	Monosomy 3q13
Chromosome 3, Monosomy 3q13	Del(3)(Q13)

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07668	LIMS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LIMS1	VGNC	VGNC:81113
Macaca mulatta	LIMS1	VGNC	VGNC:74271
Rattus norvegicus	LIMS1	RGD	RGD:1560732
Bos taurus	LIMS1	VGNC	VGNC:50211
Mus musculus	LIMS1	MGD	MGI:1195263
Others	LIMS1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.