MAPK12 - mitogen-activated protein kinase 12 Gene

Homo sapiens

Also known as ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA

Gene ID: 6300 | Gene type: protein coding

About MAPK12

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,252,901-50,261,683 (from NCBI)

This gene has 11 transcripts (splice variants), 288 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 6.0), prostate (RPKM 5.7) and 24 other tissues.

Summary

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

MAPK12 Products(2)

mRNA	Protein	Name
NM_002969.6	NP_002960.2	mitogen-activated protein kinase 12 isoform 1
NM_001303252.3	NP_001290181.1	mitogen-activated protein kinase 12 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10508788	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12761180	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8633070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in myoblast differentiation	IDA IDA: Inferred from direct assay	8633070	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15850461	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK12 Protein Structure

Pkinase

0
100
200
300
367 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 12

MAP kinase 12	MAP kinase p38 gamma
extracellular signal-regulated kinase 6	mitogen-activated protein kinase 3
mitogen-activated protein kinase p38 gamma	stress-activated protein kinase 3

MAPK12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAPK12	P53778	DLG1	Homo sapiens	Q12959	PLA	25241761
Intra	MAPK12	P53778	PKN1	Homo sapiens	Q16512	Anti Tag CoIP	12761180
Intra	MAPK12	P53778	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPK12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76532	p38 gamma/MAPK12 Protein, Human (sf9)	P53778-1 (N-G&P, M1-L367)	≥95%
HY-P76533	p38 gamma/MAPK12 Protein, Human (sf9, His-GST)	P53778-1 (M1-L367)	≥95%

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Spinocerebellar Ataxia, X-Linked 5

SCAX5	X-Linked Spinocerebellar Ataxia 5
X-Linked Non Progressive Cerebellar Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08101	MAPK12 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08102	Mapk12 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08103	Mapk12 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAPK12	RGD	RGD:70975
Macaca mulatta	MAPK12	VGNC	VGNC:74643
Mus musculus	MAPK12	MGD	MGI:1353438
Bos taurus	MAPK12	VGNC	VGNC:31215
Canis familiaris	MAPK12	VGNC	VGNC:42993
Others	MAPK12	NCBI

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