2. Gene
  3. PKN1 - protein kinase N1 Gene

PKN1 - protein kinase N1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

Gene ID: 5585 | Gene type: protein coding

About PKN1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,433,306-14,471,859 (from NCBI)

This gene has 15 transcripts (splice variants), 290 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 39.4), fat (RPKM 30.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by Phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate Insulin signals to the actin Cytoskeleton. The proteolytic activation of this kinase by Caspase-3 or related proteases during Apoptosis suggests its role in signal transduction related to Apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PKN1 Products(2)

mRNA Protein Name
NM_002741.5 NP_002732.3 serine/threonine-protein kinase N1 isoform 2
NM_213560.3 NP_998725.1 serine/threonine-protein kinase N1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
18066052 GOA
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: Inferred from Experiment
18066052 GOA
enables histone H3T11 kinase activity IDA
IDA: Inferred from direct assay
18066052 GOA
enables histone binding IDA
IDA: Inferred from direct assay
18066052 GOA
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
20188095 GOA
enables nuclear androgen receptor binding IDA
IDA: Inferred from direct assay
12514133 GOA
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
12514133 GOA
enables nuclear receptor coactivator activity IMP
IMP: Inferred from mutant phenotype
18066052 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12761180 GOA
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
20228790 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
20188095 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
9478917 GOA
Biological Process GO Annotation Evidence Reference Source
involved in epithelial cell migration IMP
IMP: Inferred from mutant phenotype
21754995 GOA
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
18066052 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17332740 GOA
involved in regulation of cell motility IMP
IMP: Inferred from mutant phenotype
21754995 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12514133 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18066052 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cleavage furrow IDA
IDA: Inferred from direct assay
17332740 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12514133 GOA
located in endosome IDA
IDA: Inferred from direct assay
9478917 GOA
located in midbody IDA
IDA: Inferred from direct assay
17332740 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12514133 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23223530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKN1 Protein Structure

HR1

HR1: Hr1 repeat (39 - 103)

HR1

HR1: Hr1 repeat (127 - 192)

HR1

HR1: Hr1 repeat (214 - 284)

Pkinase

Pkinase: Protein kinase domain (616 - 874)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (895 - 939)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 942 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase N1

protease-activated kinase 1

PKN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PKN1 Q16512 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
PKN1 Q16512 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
PKN1 Q16512 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
PKN1 Q16512 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
PKN1 Q16512 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Prey Pooling
25416956
Intra
PKN1 Q16512 CCDC103 Homo sapiens Q8IW40
Y2H Array
32296183
Intra
PKN1 Q16512 CCDC103 Homo sapiens Q8IW40
Validated Y2H
32296183
Intra
PKN1 Q16512 CCDC103 Homo sapiens Q8IW40
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 SYCE3 Homo sapiens A1L190
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 SYCE3 Homo sapiens A1L190
Y2H Array
32296183
Intra
PKN1 Q16512 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra
PKN1 Q16512 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
PKN1 Q16512 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
PKN1 Q16512 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
PKN1 Q16512 CCDC138 Homo sapiens Q96M89-2
Y2H Array
32296183
Intra
PKN1 Q16512 CCDC138 Homo sapiens Q96M89-2
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 CCDC138 Homo sapiens Q96M89-2
Validated Y2H
32296183
Intra
PKN1 Q16512 ZFP90 Homo sapiens Q8TF47
Validated Y2H
32296183
Intra
PKN1 Q16512 ZFP90 Homo sapiens Q8TF47
Y2H Array
32296183
Intra
PKN1 Q16512 ZFP90 Homo sapiens Q8TF47
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
PKN1 Q16512 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
PKN1 Q16512 AKAP9 Homo sapiens Q6PJH3
Validated Y2H
32296183
Intra
PKN1 Q16512 AKAP9 Homo sapiens Q6PJH3
Y2H Array
32296183
Intra
PKN1 Q16512 AKAP9 Homo sapiens Q6PJH3
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 CEP57 Homo sapiens Q86XR8-3
Y2H Array
32296183
Intra
PKN1 Q16512 CEP57 Homo sapiens Q86XR8-3
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 CEP57 Homo sapiens Q86XR8-3
Validated Y2H
32296183
Intra
PKN1 Q16512 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
25416956
Intra
PKN1 Q16512 CDR2 Homo sapiens Q01850
Validated Y2H
25416956
Intra
PKN1 Q16512 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 CDR2 Homo sapiens Q01850
Y2H Array
25416956
Intra
PKN1 Q16512 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
PKN1 Q16512 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
PKN1 Q16512 RAB3IP Homo sapiens Q96QF0-7
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 RAB3IP Homo sapiens Q96QF0-7
Validated Y2H
32296183
Intra
PKN1 Q16512 RAB3IP Homo sapiens Q96QF0-7
Y2H Array
32296183
Intra
PKN1 Q16512 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
PKN1 Q16512 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
PKN1 Q16512 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
PKN1 Q16512 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 C2orf15 Homo sapiens Q8WU43
Validated Y2H
32814053
Intra
PKN1 Q16512 C2orf15 Homo sapiens Q8WU43
Y2H Array
32814053
Intra
PKN1 Q16512 C2orf15 Homo sapiens Q8WU43
Y2H Pooling
32814053
Intra
PKN1 Q16512 THAP3 Homo sapiens Q8WTV1
Y2H Array
32814053
Intra
PKN1 Q16512 THAP3 Homo sapiens Q8WTV1
Validated Y2H
32814053
Intra
PKN1 Q16512 THAP3 Homo sapiens Q8WTV1
Y2H Pooling
32814053
Intra
PKN1 Q16512 UBR2 Homo sapiens Q8IWV8-2
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 UBR2 Homo sapiens Q8IWV8-2
Validated Y2H
32296183
Intra
PKN1 Q16512 UBR2 Homo sapiens Q8IWV8-2
Y2H Array
32296183
Intra
PKN1 Q16512 ARSA Homo sapiens P15289
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 ARSA Homo sapiens P15289
Y2H Array
32296183
Intra
PKN1 Q16512 CCNJL Homo sapiens Q8IV13
Y2H Array
32814053
Intra
PKN1 Q16512 CCNJL Homo sapiens Q8IV13
Validated Y2H
32814053
Intra
PKN1 Q16512 CCNJL Homo sapiens Q8IV13
Y2H Pooling
32814053
Intra
PKN1 Q16512 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Intra
PKN1 Q16512 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 MID1 Homo sapiens O15344
Y2H Array
25416956
Intra
PKN1 Q16512 LRRC61 Homo sapiens Q9BV99
Validated Y2H
32296183
Intra
PKN1 Q16512 LRRC61 Homo sapiens Q9BV99
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 LRRC61 Homo sapiens Q9BV99
Y2H Array
32296183
Intra
PKN1 Q16512 HAUS1 Homo sapiens Q96CS2
Y2H Array
32296183
Intra
PKN1 Q16512 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 HAUS1 Homo sapiens Q96CS2
Validated Y2H
32296183
Intra
PKN1 Q16512 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
PKN1 Q16512 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
PKN1 Q16512 MIPOL1 Homo sapiens Q8TD10
Y2H Array
32296183
Intra
PKN1 Q16512 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
32296183
Intra
PKN1 Q16512 MIER1 Homo sapiens Q8N108-16
Y2H Array
32814053
Intra
PKN1 Q16512 MIER1 Homo sapiens Q8N108-16
Y2H Pooling
32814053
Intra
PKN1 Q16512 MIER1 Homo sapiens Q8N108-16
Validated Y2H
32814053
Intra
PKN1 Q16512 ZNF488 Homo sapiens Q96MN9-2
Validated Y2H
32814053
Intra
PKN1 Q16512 ZNF488 Homo sapiens Q96MN9-2
Y2H Pooling
32814053
Intra
PKN1 Q16512 ZNF488 Homo sapiens Q96MN9-2
Y2H Array
32814053
Intra
PKN1 Q16512 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 PNMA1 Homo sapiens Q8ND90
Validated Y2H
32296183
Intra
PKN1 Q16512 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
PKN1 Q16512 KIAA1328 Homo sapiens Q86T90
Validated Y2H
32296183
Intra
PKN1 Q16512 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra
PKN1 Q16512 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 SMYD3 Homo sapiens Q9H7B4
Y2H Array
32296183
Intra
PKN1 Q16512 SMYD3 Homo sapiens Q9H7B4
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 SMYD3 Homo sapiens Q9H7B4
Validated Y2H
32296183
Intra
PKN1 Q16512 EEF1G Homo sapiens P26641
Validated Y2H
32814053
Intra
PKN1 Q16512 EEF1G Homo sapiens P26641
Y2H Array
32814053
Intra
PKN1 Q16512 EEF1G Homo sapiens P26641
Y2H Pooling
32814053
Intra
PKN1 Q16512 VIM Homo sapiens P08670
Y2H Array
25416956
Intra
PKN1 Q16512 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
PKN1 Q16512 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
PKN1 Q16512 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
PKN1 Q16512 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
PKN1 Q16512 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
PKN1 Q16512 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
PKN1 Q16512 SPAG5 Homo sapiens Q96R06
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 SPAG5 Homo sapiens Q96R06
Validated Y2H
32296183
Intra
PKN1 Q16512 SPAG5 Homo sapiens Q96R06
Y2H Array
32296183
Intra
PKN1 Q16512 NEFL Homo sapiens P07196
Y2H Array
32296183
Intra
PKN1 Q16512 NEFL Homo sapiens P07196
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
PKN1 Q16512 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
PKN1 Q16512 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
PKN1 Q16512 MAPK12 Homo sapiens P53778
Anti Tag CoIP
12761180
Intra
PKN1 Q16512 PSMB4 Homo sapiens P28070
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 PSMB4 Homo sapiens P28070
Y2H Array
32296183
Intra
PKN1 Q16512 GABPB1 Homo sapiens Q06547-2
Validated Y2H
32814053
Intra
PKN1 Q16512 GABPB1 Homo sapiens Q06547-2
Y2H Pooling
32814053
Intra
PKN1 Q16512 GABPB1 Homo sapiens Q06547-2
Y2H Array
32814053
Intra
PKN1 Q16512 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
PKN1 Q16512 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PKN1 Q16512 MAP3K20 Homo sapiens Q9NYL2-1
Anti Tag CoIP
12761180
Intra
PKN1 Q16512 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
PKN1 Q16512 EIF3F Homo sapiens O00303
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 EIF3F Homo sapiens O00303
Y2H Array
32296183
Intra
PKN1 Q16512 HAP1 Homo sapiens P54257
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 HAP1 Homo sapiens P54257
Y2H Array
32296183
Intra
PKN1 Q16512 STX11 Homo sapiens O75558
Y2H Array
32296183
Intra
PKN1 Q16512 STX11 Homo sapiens O75558
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
PKN1 Q16512 STMN3 Homo sapiens Q9NZ72
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 STMN3 Homo sapiens Q9NZ72
Validated Y2H
32296183
Intra
PKN1 Q16512 STMN3 Homo sapiens Q9NZ72
Y2H Array
32296183
Intra
PKN1 Q16512 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra
PKN1 Q16512 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
PKN1 Q16512 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
PKN1 Q16512 CCDC85B Homo sapiens Q15834
Pull Down
16189514
Intra
PKN1 Q16512 CCDC85B Homo sapiens Q15834
Y2H Pooling
16189514
Intra
PKN1 Q16512 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
PKN1 Q16512 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra
PKN1 Q16512 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
Intra
PKN1 Q16512 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
32296183
Intra
PKN1 Q16512 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra
PKN1 Q16512 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KCTD17 Homo sapiens Q8N5Z5
Y2H Array
32814053
Intra
PKN1 Q16512 KCTD17 Homo sapiens Q8N5Z5
Y2H Pooling
32814053
Intra
PKN1 Q16512 KCTD17 Homo sapiens Q8N5Z5
Validated Y2H
32814053
Intra
PKN1 Q16512 TSGA10 Homo sapiens Q9BZW7
Y2H Array
32296183
Intra
PKN1 Q16512 TSGA10 Homo sapiens Q9BZW7
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 TSGA10 Homo sapiens Q9BZW7
Validated Y2H
32296183
Intra
PKN1 Q16512 ZNF581 Homo sapiens Q9P0T4
Y2H Pooling
32814053
Intra
PKN1 Q16512 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32814053
Intra
PKN1 Q16512 ZNF581 Homo sapiens Q9P0T4
Y2H Array
32814053
Intra
PKN1 Q16512 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
PKN1 Q16512 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
PKN1 Q16512 INTS11 Homo sapiens Q5TA45
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 INTS11 Homo sapiens Q5TA45
Validated Y2H
32296183
Intra
PKN1 Q16512 INTS11 Homo sapiens Q5TA45
Y2H Array
32296183
Intra
PKN1 Q16512 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
25416956
Intra
PKN1 Q16512 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra
PKN1 Q16512 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
PKN1 Q16512 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra
PKN1 Q16512 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra
PKN1 Q16512 ZNF232 Homo sapiens Q9UNY5
Y2H Array
32814053
Intra
PKN1 Q16512 ZNF232 Homo sapiens Q9UNY5
Y2H Pooling
32814053
Intra
PKN1 Q16512 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32814053
Intra
PKN1 Q16512 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
PKN1 Q16512 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
PKN1 Q16512 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
PKN1 Q16512 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
PKN1 Q16512 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
PKN1 Q16512 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
PKN1 Q16512 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
PKN1 Q16512 BECN1 Homo sapiens Q14457
Validated Y2H
32814053
Intra
PKN1 Q16512 BECN1 Homo sapiens Q14457
Y2H Pooling
32814053
Intra
PKN1 Q16512 BECN1 Homo sapiens Q14457
Y2H Array
32814053
Cross
PKN1 Q16512 yopM Yersinia enterocolitica serotype O:8/biotype 1B A1JU68
Anti Bait CoIP
25513777
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mevalonic Aciduria

Mevalonate Kinase Deficiency

Mevalonicaciduria

Hyperimmunoglobulin D With Periodic Fever

MEVA

Complete Mevalonate Kinase Deficiency

Mva

Hyperimmunoglobulinemia D

Hyper Igd Syndrome

Periodic Fever, Dutch Type

Mkd

Aciduria, Mevalonic

Deficiency Of Mevalonate Kinase
Malignant Acrospiroma

Eccrine Ductal Carcinoma

Hidradenocarcinoma

Anaplastic Syringoma

Eccrine Ductal Carcinoma Of Skin

Clear Cell Eccrine Carcinoma

Malignant Clear Cell Acrospiroma

Malignant Nodular/Clear Cell Hidradenoma

Primary Mucoepidermoid Cutaneous Carcinoma

Sweat Gland Adenocarcinoma
Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2

Acromegaly Due To Pituitary Adenoma 2

Acromegaly, X-Linked

Growth Hormone Secreting Pituitary Adenoma 2

Pituitary Adenoma, Growth Hormone-Secreting, 2

Pituitary Adenoma 2, Gh-Secreting

Gh-Secreting Pituitary Adenoma 2

X-Linked Acromegaly

Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Bubonic Plague

Black Death

Plague, Bubonic

Plague, Septicemic

Pestis Bubonica
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145899 PKN1/2-IN-1 Inhibitor 98.48% Unkown
HY-RS10606 PKN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PKN1 VGNC VGNC:69063
Macaca mulatta PKN1 VGNC VGNC:76014
Bos taurus PKN1 VGNC VGNC:32945
Canis familiaris PKN1 VGNC VGNC:44611
Rattus norvegicus PKN1 RGD RGD:69308
Mus musculus PKN1 MGD MGI:108022
Others PKN1 NCBI