2. Gene
  3. CLEC11A - C-type lectin domain containing 11A Gene

CLEC11A - C-type lectin domain containing 11A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P47; SCGF; LSLCL; CLECSF3

Gene ID: 6320 | Gene type: protein coding

About CLEC11A

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,723,364-50,725,708 (from NCBI)

This gene has 2 transcripts (splice variants), 174 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 36.6), endometrium (RPKM 6.5) and 15 other tissues.

Summary

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

CLEC11A Products(1)

mRNA Protein Name
NM_002975.3 NP_002966.1 C-type lectin domain family 11 member A precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables growth factor activity IDA
IDA: Inferred from direct assay
11920266 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11920266 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular region IDA
IDA: Inferred from direct assay
9442024 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC11A Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (198 - 321)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 11 member A

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3

CLEC11A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CLEC11A Q9Y240 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra CLEC11A Q9Y240 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra CLEC11A Q9Y240 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra CLEC11A Q9Y240 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra CLEC11A Q9Y240 TTR Homo sapiens P02766
Y2H Array
32814053
Intra CLEC11A Q9Y240 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra CLEC11A Q9Y240 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra CLEC11A Q9Y240 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra CLEC11A Q9Y240 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra CLEC11A Q9Y240 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra CLEC11A Q9Y240 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Benign Mastocytoma
Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked
Piebald Trait

Piebaldism

PBT

Partial Albinism

Albinoidism, Oculocutaneous, Autosomal Dominant
Esophageal Lipoma

Lipoma Of Esophagus
Solitary Mastocytoma Of The Skin

Cutaneous Solitary Mastocytoma

Skin Mastocytoma

Solitary Mastocytoma

Solitary Mastocytoma Of Skin

Mastocytoma, Skin
Aggressive Systemic Mastocytosis

Asm

Lymphadenopathic Mastocytosis With Eosinophilia
Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones
Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02780 CLEC11A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLEC11A RGD RGD:3627
Mus musculus CLEC11A MGD MGI:1298219
Macaca mulatta CLEC11A VGNC VGNC:71167
Bos taurus CLEC11A VGNC VGNC:27422
Canis familiaris CLEC11A VGNC VGNC:49644
Others CLEC11A NCBI