BICD1 - BICD cargo adaptor 1 Gene

Homo sapiens

Also known as BICD; bic-D 1

Gene ID: 636 | Gene type: protein coding

About BICD1

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:32,106,847-32,383,633 (from NCBI)

This gene has 10 transcripts (splice variants), 268 orthologues and 1 paralogue. Broad expression in ovary (RPKM 4.3), brain (RPKM 3.8) and 20 other tissues.

Summary

This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in Other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]

BICD1 Products(34)

mRNA	Protein	Name
NM_001003398.3	NP_001003398.1	protein bicaudal D homolog 1 isoform 2
NM_001354186.2	NP_001341115.1	protein bicaudal D homolog 1 isoform 3
NM_001354187.2	NP_001341116.1	protein bicaudal D homolog 1 isoform 4
NM_001354188.2	NP_001341117.1	protein bicaudal D homolog 1 isoform 5
NM_001354189.2	NP_001341118.1	protein bicaudal D homolog 1 isoform 6
NM_001363603.2	NP_001350532.1	protein bicaudal D homolog 1 isoform 7
NM_001413155.1	NP_001400084.1	protein bicaudal D homolog 1 isoform 2
NM_001413156.1	NP_001400085.1	protein bicaudal D homolog 1 isoform 8
NM_001413157.1	NP_001400086.1	protein bicaudal D homolog 1 isoform 9
NM_001413158.1	NP_001400087.1	protein bicaudal D homolog 1 isoform 10
NM_001413159.1	NP_001400088.1	protein bicaudal D homolog 1 isoform 11
NM_001413160.1	NP_001400089.1	protein bicaudal D homolog 1 isoform 12
NM_001413161.1	NP_001400090.1	protein bicaudal D homolog 1 isoform 13
NM_001413163.1	NP_001400092.1	protein bicaudal D homolog 1 isoform 14
NM_001413164.1	NP_001400093.1	protein bicaudal D homolog 1 isoform 15
NM_001413165.1	NP_001400094.1	protein bicaudal D homolog 1 isoform 16
NM_001413166.1	NP_001400095.1	protein bicaudal D homolog 1 isoform 17
NM_001413167.1	NP_001400096.1	protein bicaudal D homolog 1 isoform 18
NM_001413168.1	NP_001400097.1	protein bicaudal D homolog 1 isoform 19
NM_001413169.1	NP_001400098.1	protein bicaudal D homolog 1 isoform 20
NM_001413170.1	NP_001400099.1	protein bicaudal D homolog 1 isoform 21
NM_001413171.1	NP_001400100.1	protein bicaudal D homolog 1 isoform 22
NM_001413172.1	NP_001400101.1	protein bicaudal D homolog 1 isoform 23
NM_001413173.1	NP_001400102.1	protein bicaudal D homolog 1 isoform 24
NM_001413174.1	NP_001400103.1	protein bicaudal D homolog 1 isoform 25
NM_001413176.1	NP_001400105.1	protein bicaudal D homolog 1 isoform 26
NM_001413177.1	NP_001400106.1	protein bicaudal D homolog 1 isoform 27
NM_001413178.1	NP_001400107.1	protein bicaudal D homolog 1 isoform 28
NM_001413179.1	NP_001400108.1	protein bicaudal D homolog 1 isoform 29
NM_001413180.1	NP_001400109.1	protein bicaudal D homolog 1 isoform 30
NM_001413181.1	NP_001400110.1	protein bicaudal D homolog 1 isoform 31
NM_001413182.1	NP_001400111.1	protein bicaudal D homolog 1 isoform 32
NM_001413183.1	NP_001400112.1	protein bicaudal D homolog 1 isoform 33
NM_001714.4	NP_001705.2	protein bicaudal D homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal anchor activity	IDA IDA: Inferred from direct assay	12447383	GOA
enables dynactin binding	IDA IDA: Inferred from direct assay	12447383	GOA
enables dynactin binding	IPI IPI: Inferred from physical interaction	17139249	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	12447383	GOA
enables dynein intermediate chain binding	IDA IDA: Inferred from direct assay	17139249	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17139249	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17139249	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	12447383	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in minus-end-directed organelle transport along microtubule	IMP IMP: Inferred from mutant phenotype	12447383	GOA
involved in positive regulation of protein localization to centrosome	IGI IGI: Inferred from genetic interaction	17139249	GOA
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	20164183	GOA
involved in protein localization to organelle	IDA IDA: Inferred from direct assay	12447383	GOA
involved in regulation of microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	17139249	GOA
involved in viral process	IMP IMP: Inferred from mutant phenotype	20089649	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with Golgi apparatus	IDA IDA: Inferred from direct assay	17139249	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17562788	GOA
located in centrosome	IMP IMP: Inferred from mutant phenotype	17139249	GOA
colocalizes with cytoplasmic microtubule	IDA IDA: Inferred from direct assay	20089649	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12447383	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12447383	GOA
located in membrane	IDA IDA: Inferred from direct assay	12447383	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20089649	GOA
located in perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	17139249	GOA
located in secretory vesicle	IDA IDA: Inferred from direct assay	20089649	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12447383	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BICD1 Protein Structure

BicD

0
200
400
600
800
975 a.a.

Protein Preferred Names

Protein Names

protein bicaudal D homolog 1

bicaudal D homolog 1

BICD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	17139249
Intra	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	17139249
Intra	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Density Sedimentation	17139249
Intra	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Y2H Array	17139249
Intra	BICD1	Q96G01	STAT3	Homo sapiens	P40763	Pull Down	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Spinal Muscular Atrophy With Lower Extremity Predominant

Spinal Muscular Atrophy With Lower Extremity Predominance	Autosomal Dominant Childhood-Onset Proximal Spinal Muscular Atrophy With Contractures
Kugelberg-Welander Syndrome, Autosomal Dominant	Lower Extremity-Predominant Autosomal Dominant Proximal Spinal Muscular Atrophy With Contractures
Sma-Led	Spinal Muscular Atrophy, Childhood, Proximal, Autosomal Dominant
Spinal Muscular Atrophy, Juvenile, Proximal, Autosomal Dominant	Spinal Muscular Atrophy, Lower Extremity, Autosomal Dominant
Spinal Muscular Atrophy, Lower Extremity, Dominant

Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01498	BICD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BICD1	VGNC	VGNC:26491
Mus musculus	BICD1	MGD	MGI:1101760
Rattus norvegicus	BICD1	RGD	RGD:1309444
Macaca mulatta	BICD1	VGNC	VGNC:70249
Felis catus	BICD1	VGNC	VGNC:83508
Canis familiaris	BICD1	VGNC	VGNC:38450

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