CCL19 - C-C motif chemokine ligand 19 Gene

Homo sapiens

Also known as ELC; CKb11; MIP3B; MIP-3b; SCYA19

Gene ID: 6363 | Gene type: protein coding

About CCL19

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,689,570-34,691,276 (from NCBI)

This gene has 3 transcripts (splice variants), 96 orthologues and 25 paralogues. Biased expression in appendix (RPKM 274.6), lymph node (RPKM 208.4) and 5 other tissues.

Summary

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to Chemokine Receptor CCR7. [provided by RefSeq, Sep 2014]

CCL19 Products(1)

mRNA	Protein	Name
NM_006274.3	NP_006265.1	C-C motif chemokine 19 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR chemokine receptor binding	IPI IPI: Inferred from physical interaction	20002784	GOA
enables CCR10 chemokine receptor binding	IDA IDA: Inferred from direct assay	10706668	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	15778365	GOA
enables chemokine receptor binding	IDA IDA: Inferred from direct assay	23341447	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27044744	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	15778365	GOA
involved in establishment of T cell polarity	IDA IDA: Inferred from direct assay	12729902	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in myeloid dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	14592837	GOA
involved in negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	15778365	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15778365	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of cell motility	IDA IDA: Inferred from direct assay	15778365	GOA
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	21051556	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	14592837	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	14592837	GOA
involved in response to nitric oxide	IDA IDA: Inferred from direct assay	16249377	GOA
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	14592837	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL19 Protein Structure

IL8

0
98 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 19

CC chemokine ligand 19

CCL19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCL19	Q99731	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CCL19	Q99731	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CCL19 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81925	CCL19 Antibody (YA1670)	WB, FC	Human
HY-P83178	CCL19 beta Antibody (YA2923)	WB	Human

Related Diseases

Diseases

Alias

Polyradiculoneuropathy

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Primary Central Nervous System Lymphoma

Pcnsl	Primary Cns Lymphoma
Primary Brain Lymphoma	Primary Lymphoma, Cns
Primary Cerebral Lymphoma

B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma	B-All
Precursor B Lymphoblastic Lymphoma/Leukemia	C-All
Lymphoblastic Lymphoma, Nos	Common Precursor B All
Lymphoblastic B-Cell Lymphoma	Pro-B All
B-Precursor Lymphoma	Lbl - [Lymphoblastic Lymphoma]

Sodoku Disease

Spirillosis	Sodoku
Spirillary Fever	Rat-Bite Fever
Rat-Bite Fever Due To Spirillum Minus	Spirillary Rat-Bite Fever
Sokosho

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133073	CCR7 Ligand 1	Antagonist	99.62%	Unkown
HY-120427	Cosalane		99.78%	Unkown
HY-RS02088	CCL19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCL19	VGNC	VGNC:26946
Canis familiaris	CCL19	VGNC	VGNC:38883
Mus musculus	CCL19	MGD	MGI:1346316
Felis catus	CCL19	VGNC	VGNC:60541
Rattus norvegicus	CCL19	RGD	RGD:1310336
Macaca mulatta	CCL19	VGNC	VGNC:70697
Others	CCL19	NCBI

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