2. GPCR/G Protein Immunology/Inflammation PROTAC
  3. CCR Ligands for Target Protein for PROTAC
  4. CCR7 Ligand 1

CCR7 Ligand 1  (Synonyms: CCR7-Cmp2105)

Cat. No.: HY-133073 Purity: 99.62%
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CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.

For research use only. We do not sell to patients.

CCR7 Ligand 1 Chemical Structure

CCR7 Ligand 1 Chemical Structure

CAS No. : 681514-83-0

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50 mg USD 2950 In-stock
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Based on 1 publication(s) in Google Scholar

CCR7 Ligand 1 Related Antibodies

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Description

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].

IC50 & Target[1]

Human CCR7

3 nM (Kd)

In Vitro

CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8[1].
CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM[1].
CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCR7 Ligand 1 Related Antibodies
Molecular Weight

475.56

Formula

C22H29N5O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C)C)C1=C(C)C=CC(NC(C(N[C@@H](C2=CC=C(C)O2)C(C)(C)C)=N3)=NS3(=O)=O)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1028 mL 10.5139 mL 21.0278 mL
5 mM 0.4206 mL 2.1028 mL 4.2056 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1028 mL 10.5139 mL 21.0278 mL 52.5696 mL
5 mM 0.4206 mL 2.1028 mL 4.2056 mL 10.5139 mL
10 mM 0.2103 mL 1.0514 mL 2.1028 mL 5.2570 mL
15 mM 0.1402 mL 0.7009 mL 1.4019 mL 3.5046 mL
20 mM 0.1051 mL 0.5257 mL 1.0514 mL 2.6285 mL
25 mM 0.0841 mL 0.4206 mL 0.8411 mL 2.1028 mL
30 mM 0.0701 mL 0.3505 mL 0.7009 mL 1.7523 mL
40 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.3142 mL
50 mM 0.0421 mL 0.2103 mL 0.4206 mL 1.0514 mL
60 mM 0.0350 mL 0.1752 mL 0.3505 mL 0.8762 mL
80 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6571 mL
100 mM 0.0210 mL 0.1051 mL 0.2103 mL 0.5257 mL
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CCR7 Ligand 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR7 Ligand 1681514-83-0CCR7-Cmp2105CCRLigands for Target Protein for PROTACCC chemokine receptorTarget Protein-binding MoietyallostericLigandCCchemokinereceptor7thiadiazole-dioxideliganCCL19Inhibitorinhibitorinhibit

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