CXCL11 - C-X-C motif chemokine ligand 11 Gene

Homo sapiens

Also known as IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B

Gene ID: 6373 | Gene type: protein coding

About CXCL11

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:76,033,682-76,036,070 (from NCBI)

This gene has 2 transcripts (splice variants), 88 orthologues and 12 paralogues. Broad expression in appendix (RPKM 6.2), lymph node (RPKM 5.0) and 21 other tissues.

Summary

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

CXCL11 Products(2)

mRNA	Protein	Name
NM_001302123.2	NP_001289052.1	C-X-C motif chemokine 11 isoform 2 precursor
NM_005409.5	NP_005400.1	C-X-C motif chemokine 11 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables CXCR3 chemokine receptor binding	IDA IDA: Inferred from direct assay	12782716	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	12782716	GOA
enables heparin binding	IMP IMP: Inferred from mutant phenotype	18645041	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18275857	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18645041	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12782716	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18645041	GOA
involved in chemotaxis	IDA IDA: Inferred from direct assay	12782716	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	12782716	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12782716	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL11 Protein Structure

IL8

0
94 a.a.

Protein Preferred Names

Protein Names

C-X-C motif chemokine 11

beta-R1

CXCL11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CXCL11	O14625	PF4V1	Homo sapiens	P10720	Filter Binding	28381538
Intra	CXCL11	O14625	CCL24	Homo sapiens	O00175	Filter Binding	28381538
Intra	CXCL11	O14625	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CXCL11	O14625	CXCL14	Homo sapiens	O95715	Filter Binding	28381538
Intra	CXCL11	O14625	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CXCL11	O14625	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CXCL11	O14625	DPP4	Homo sapiens	P27487	Enzymatic Study	18275857
Intra	CXCL11	O14625	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	CXCL11	O14625	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	CXCL11	O14625	CCL13	Homo sapiens	Q99616	Filter Binding	28381538
Intra	CXCL11	O14625	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	CXCL11	O14625	CCL26	Homo sapiens	Q9Y258	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7228	I-TAC/CXCL11 Protein, Human (HEK293)	O14625 (F22-F94)	≥95%
HY-P7229	I-TAC/CXCL11 Protein, Human	O14625 (F22-F94)	≥95%
HY-P700042AF	Animal-Free I-TAC/CXCL11 Protein, Human (His)	O14625 (F22-F94)	≥95%

Related Diseases

Diseases

Alias

Nasal Cavity Adenocarcinoma

Adenocarcinoma Of Nasal Cavity

Adenocarcinoma Of The Nasal Cavity

Nasal Cavity Cancer

Nasal Cavity Carcinoma	Malignant Neoplasm Of Nasal Cavities
Malignant Tumor Of The Nasal Cavity	Cancer Of Nasal Cavity
Carcinoma Of Nasal Cavity	Malignant Neoplasm Of Nasal Cavity
Neoplasm Of Nasal Cavity

Mycosis Fungoides

Mycosis Fungoides Lymphoma	Alibert-Bazin Syndrome
Granuloma Fungoides	Classic Mycosis Fungoides
Mycosis Fungoides, Alibert-Bazin Type

American Histoplasmosis

Infection By Histoplasma Capsulatum

Ethmoid Sinus Adenocarcinoma

Adenocarcinoma Of Ethmoid Sinus

Adenocarcinoma Of The Ethmoid Sinus

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Cryoglobulinemia

Cryoimmunoglobulinaemia

Breast Duct Papilloma

Intraductal Papilloma Of Breast	Duct Papilloma Of Breast
Papilloma Of The Breast

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms	Relapsing Remitting Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting	Rrms
Multiple Sclerosis Relapsing-Remitting

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Nasal Cavity Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Nasal Cavity

Squamous Cell Carcinoma Of The Nasal Cavity

Maxillary Sinus Adenocarcinoma

Adenocarcinoma Of Maxillary Sinus

Adenocarcinoma Of The Maxillary Sinus

Ethmoid Sinus Cancer

Malignant Neoplasm Of Ethmoidal Sinus	Malignant Tumor Of Ethmoid Sinus
Malignant Tumor Of Ethmoidal Sinus	Neoplasm Of Ethmoidal Sinus

Retroperitoneal Hemangiopericytoma

Sinonasal Undifferentiated Carcinoma

Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Snuc

Paranasal Sinus Cancer

Paranasal Sinus Adenoid Cystic Carcinoma	Paranasal Sinus Mucoepidermoid Carcinoma
Paranasal Sinus Squamous Cell Carcinoma	Paranasal Sinus Neoplasms
Adenoid Cystic Carcinoma Of Accessory Sinus	Adenoid Cystic Carcinoma Of Paranasal Sinus
Epidermoid Carcinoma Of The Paranasal Sinus	Mucoepidermoid Carcinoma Of Accessory Sinus
Paranasal Sinus Adenocarcinoma	Squamous Cell Carcinoma Of Paranasal Sinus
Paranasal Sinus Neoplasm	Adenocarcinoma Of Accessory Sinus

Olmsted Syndrome, X-Linked

OLMSX	Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked
Ppkmx	X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
X-Linked Olmsted Syndrome	Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Pediculus Humanus Corporis Infestation

Body Louse Infestation	Pediculus Corporis
Pediculus Humanus Infestation

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Immunodeficiency 27a

IMD27A	Autosomal Recessive Ifngr1 Deficiency
Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive
Ifngr1 Deficiency, Autosomal Recessive	Immunodeficiency 27a, Mycobacteriosis, Ar
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency	Msmd Due To Complete Ifngammar1 Deficiency
Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency
Familial Disseminated Atypical Mycobacterial Infection	Interferon Gamma, Receptor 1, Deficiency
Immunodeficiency, Type 27a, Mycobacteriosis, Ar	Mycobacterial Disease, Mendelian Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15319	AMG 487	Inhibitor	99.65%	Unkown
HY-139643	CXCR7 antagonist-1	Antagonist	99.85%	Unkown
HY-15320	NBI-74330	Antagonist	98.57%	Unkown
HY-149055	ACT-777991	Antagonist	99.86%	Unkown
HY-139643A	CXCR7 antagonist-1 hydrochloride	Antagonist	99.66%	Unkown
HY-15319A	(±)-AMG 487	Inhibitor	/	Unkown
HY-RS03385	CXCL11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W505771	Seselin	Inhibitor	98.48%	Unkown
HY-113730	VUF5834		/	Unkown
HY-167884	PF-1367550	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CXCL11	RGD	RGD:727827
Macaca mulatta	CXCL11	VGNC	VGNC:106564
Mus musculus	CXCL11	MGD	MGI:1860203
Felis catus	CXCL11	VGNC	VGNC:78477
Bos taurus	CXCL11	VGNC	VGNC:27847
Susscrofa domestica	CXCL11	NCBI
Others	CXCL11	NCBI

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