UBE2O - ubiquitin conjugating enzyme E2 O Gene

Homo sapiens

Also known as E2-230K

Gene ID: 63893 | Gene type: protein coding

About UBE2O

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,389,456-76,453,152 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 12.9), testis (RPKM 11.1) and 25 other tissues.

Summary

Enables ubiquitin conjugating Enzyme activity and ubiquitin protein Ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

UBE2O Products(1)

mRNA	Protein	Name
NM_022066.4	NP_071349.3	(E3-independent) E2 ubiquitin-conjugating enzyme

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	23455153	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	23455153	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23455153	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	23455153	GOA
involved in protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	23452853	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	23455153	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	23452853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24703950	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24703950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2O Protein Structure

UQ_con

0
200
400
600
800
1000
1200
1292 a.a.

Protein Preferred Names

Protein Names

(E3-independent) E2 ubiquitin-conjugating enzyme

E2/E3 hybrid ubiquitin-protein ligase UBE2O

UBE2O Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBE2O	Q9C0C9	SFMBT2	Homo sapiens	Q5VUG0	Y2H Prey Pooling	32296183
Intra	UBE2O	Q9C0C9	SFMBT2	Homo sapiens	Q5VUG0	Y2H Array	32296183
Intra	UBE2O	Q9C0C9	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	UBE2O	Q9C0C9	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	UBE2O	Q9C0C9	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	UBE2O	Q9C0C9	GNB2	Homo sapiens	P62879	Y2H Array	32814053
Intra	UBE2O	Q9C0C9	GNB2	Homo sapiens	P62879	Validated Y2H	32814053
Intra	UBE2O	Q9C0C9	GNB2	Homo sapiens	P62879	Y2H Pooling	32814053
Cross	UBE2O	Q9C0C9	Smad6	Mus musculus	O35182	Anti Tag CoIP	23455153
Cross	UBE2O	Q9C0C9	Smad7	Mus musculus	O35253	Anti Tag CoIP	23455153
Intra	UBE2O	Q9C0C9	APPL1	Homo sapiens	Q9UKG1	Validated Y2H	32296183
Intra	UBE2O	Q9C0C9	APPL1	Homo sapiens	Q9UKG1	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 2a

Pontocerebellar Hypoplasia Type 2a	PCH2A
Pch2	Pontocerebellar Hypoplasia With Progressive Cerebral Atrophy
Volendam Neurodegenerative Disease	Pontocerebellar Hypoplasia 2a
Hypoplasia, Pontocerebellar, Type 2a

Pontocerebellar Hypoplasia, Type 16

PCH16	Pontocerebellar Hypoplasia Type 16
Pontocerebellar Hypoplasia 16	Doid:0112333

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128912	Arborinine	Inhibitor	/	Unkown
HY-RS15357	UBE2O Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2O	MGD	MGI:2444266
Macaca mulatta	UBE2O	VGNC	VGNC:79813
Felis catus	UBE2O	VGNC	VGNC:99567
Bos taurus	UBE2O	VGNC	VGNC:36591
Rattus norvegicus	UBE2O	RGD	RGD:1310297
Canis familiaris	UBE2O	VGNC	VGNC:48060
Others	UBE2O	NCBI

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