Smad7 - SMAD family member 7 Gene

Mus musculus

Also known as Madh7

Gene ID: 17131 | Gene type: protein coding

About Smad7

Summary

Enables collagen binding activity. Involved in several processes, including circulatory system development; negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and negative regulation of protein phosphorylation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of BMP signaling pathway; and transforming growth factor beta receptor signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in colorectal Cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (Smad Family member 7). [provided by Alliance of Genome Resources, Apr 2022]

Smad7 Products(1)

mRNA	Protein	Name
NM_001042660.1	NP_001036125.1	mothers against decapentaplegic homolog 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IPI IPI: Inferred from physical interaction	14559231	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16601693	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in artery morphogenesis	IMP IMP: Inferred from mutant phenotype	18952608	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in cellular response to transforming growth factor beta stimulus	IMP IMP: Inferred from mutant phenotype	18593713	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	19850029	MGI
involved in negative regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	18952608	MGI
involved in negative regulation of T cell cytokine production	IMP IMP: Inferred from mutant phenotype	25642768	MGI
involved in negative regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	25642768	MGI
involved in negative regulation of T-helper 17 type immune response	IMP IMP: Inferred from mutant phenotype	25642768	MGI
involved in negative regulation of chondrocyte proliferation	IDA IDA: Inferred from direct assay	29503843	MGI
involved in negative regulation of ossification	IDA IDA: Inferred from direct assay	29503843	MGI
involved in negative regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18593713	MGI
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	18593713	MGI
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18593713	MGI
involved in positive regulation of chondrocyte hypertrophy	IDA IDA: Inferred from direct assay	29503843	MGI
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	18952608	MGI
involved in regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18952608	MGI
involved in regulation of ventricular cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	18952608	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	11557747	MGI
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	14656760	MGI
involved in ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	18952608	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	18952608	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16601693	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	16601693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mothers against decapentaplegic homolog 7

MAD homolog 7	MAD homolog 8
SMAD 7	madh8
mothers against DPP homolog 7	mothers against DPP homolog 8
mothers against decapentaplegic homolog 8

Smad7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Smad7	O35253	Sirt1	Mus musculus	Q923E4	Anti Tag CoIP	17098745
Intra	Smad7	O35253	Sirt1	Mus musculus	Q923E4	Anti Bait CoIP	17098745
Intra	Smad7	O35253	Axin1	Mus musculus	O35625	Anti Tag CoIP	16601693

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145721	Mongersen	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0439	Asiaticoside		99.84%	Unkown
HY-145721A	Mongersen sodium		99.61%	Unkown
HY-170791	CIB-L43		/	Unkown
HY-RS13398	SMAD7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N13208	Stevia Powder		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smad7	NCBI	NCBI:4092

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