SEL1L - SEL1L adaptor subunit of ERAD E3 ubiquitin ligase Gene

Homo sapiens

Also known as Hrd3; SEL1L1; PRO1063; SEL1-LIKE

Gene ID: 6400 | Gene type: protein coding

About SEL1L

Cytogenetic location: 14q31.1 Genomic coordinates (GRCh38): 14:81,471,547-81,533,853 (from NCBI)

This gene has 6 transcripts (splice variants), 214 orthologues and 4 paralogues. Ubiquitous expression in pancreas (RPKM 48.9), thyroid (RPKM 38.9) and 25 other tissues.

Summary

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the Proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SEL1L Products(2)

mRNA	Protein	Name
NM_001244984.2	NP_001231913.1	protein sel-1 homolog 1 isoform 2 precursor
NM_005065.6	NP_005056.3	protein sel-1 homolog 1 isoform 1 precursor

SEL1L Protein Structure

fn2

Sel1

0
200
400
600
794 a.a.

Protein Preferred Names

Protein Names

protein sel-1 homolog 1

SEL1L, ERAD E3 ligase adaptor subunit

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 11

Diabetes Mellitus, Insulin-Dependent, 11	Iddm11
Insulin-Dependent Diabetes Mellitus 11	T1D11
Insulin-Dependent Diabetes Mellitus-11

Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Lipase Deficiency, Combined

Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency	Lpl And Htgl Deficiency
Lpl And Hl Deficiency	Familial Lipase Maturation Factor 1 Deficiency
Lipase Deficiency Combined	Combined Lipase Deficiency
Familial Lmf1 Deficiency	CLD

Type 1 Diabetes Mellitus 10

Diabetes Mellitus, Insulin-Dependent, 10	IDDM10
Insulin-Dependent Diabetes Mellitus 10	Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10
T1D10	Diabetes, Mellitus, Insulin-Dependent 10
Diabetes Mellitus, Insulin-Dependent, Type 10

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12630	SEL1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12631	SEL1L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SEL1L	VGNC	VGNC:77155
Rattus norvegicus	SEL1L	RGD	RGD:620147
Mus musculus	SEL1L	MGD	MGI:1329016
Felis catus	SEL1L	VGNC	VGNC:64978
Canis familiaris	SEL1L	VGNC	VGNC:54990
Bos taurus	SEL1L	VGNC	VGNC:49962

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