OS9 - OS9 endoplasmic reticulum lectin Gene

Homo sapiens

Also known as OS-9; ERLEC2

Gene ID: 10956 | Gene type: protein coding

About OS9

Cytogenetic location: 12q13.3-q14.1 Genomic coordinates (GRCh38): 12:57,694,132-57,721,557 (from NCBI)

This gene has 37 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 82.8), thyroid (RPKM 81.3) and 25 other tissues.

Summary

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

OS9 Products(11)

mRNA	Protein	Name
NM_001017956.3	NP_001017956.1	protein OS-9 isoform 2 precursor
NM_001017957.3	NP_001017957.1	protein OS-9 isoform 3 precursor
NM_001017958.3	NP_001017958.1	protein OS-9 isoform 4 precursor
NM_001261420.2	NP_001248349.1	protein OS-9 isoform 5 precursor
NM_001261421.2	NP_001248350.1	protein OS-9 isoform 6 precursor
NM_001261422.2	NP_001248351.1	protein OS-9 isoform 7 precursor
NM_001261423.2	NP_001248352.1	protein OS-9 isoform 8 precursor
NM_001410978.1	NP_001397907.1	protein OS-9 isoform 9 precursor
NM_001410979.1	NP_001397908.1	protein OS-9 isoform 10 precursor
NM_001410980.1	NP_001397909.1	protein OS-9 isoform 11 precursor
NM_006812.4	NP_006803.1	protein OS-9 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IDA IDA: Inferred from direct assay	18264092	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15721254	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	18264092	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
involved in protein retention in ER lumen	IDA IDA: Inferred from direct assay	18417469	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	19084021	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	19084021	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19084021	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	18264092	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OS9 Protein Structure

PRKCSH

0
200
400
600
667 a.a.

Protein Preferred Names

Protein Names

protein OS-9

amplified in osteosarcoma 9

OS9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OS9	Q13438	EGLN1	Homo sapiens	Q9GZT9	Anti Tag CoIP	15721254
Intra	OS9	Q13438	ERN1	Homo sapiens	O75460-1	Anti Tag CoIP	26551274
Intra	OS9	Q13438	NXPE3	Homo sapiens	Q969Y0	Anti Tag CoIP	33961781
Intra	OS9	Q13438	SEL1L	Homo sapiens	Q9UBV2	Pull Down	22119785
Intra	OS9	Q13438	SEL1L	Homo sapiens	Q9UBV2	Anti Tag CoIP	26551274
Intra	OS9	Q13438	SEL1L	Homo sapiens	Q9UBV2	Anti Tag CoIP	33961781
Intra	OS9	Q13438	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	15721254
Intra	OS9	Q13438	HIF1A	Homo sapiens	Q16665	Pull Down	15721254

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies	FENIB
Encephalopathy, Familial, With Collins Bodies	Familial Dementia With Neuroserpin Inclusion Bodies
Familial Encephalopathy With Collins Bodies

Erythrocytosis, Familial, 3

ECYT3	Familial Erythrocytosis 3
Erythrocytosis, Familial, Type 3

Erythrocytosis, Familial, 5

ECYT5

Familial Erythrocytosis 5

Fibrosarcomatous Osteosarcoma

Fibroblastic Osteosarcoma

Fibrosarcomatous Osteogenic Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09834	OS9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	OS9	VGNC	VGNC:63975
Macaca mulatta	OS9	VGNC	VGNC:75635
Bos taurus	OS9	VGNC	VGNC:32455
Mus musculus	OS9	MGD	MGI:1924301
Rattus norvegicus	OS9	RGD	RGD:1359574
Canis familiaris	OS9	VGNC	VGNC:44148

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