LRRC4 - leucine rich repeat containing 4 Gene

Homo sapiens

Also known as NAG14; NGL-2

Gene ID: 64101 | Gene type: protein coding

About LRRC4

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,027,071-128,032,128 (from NCBI)

This gene has 4 transcripts (splice variants), 262 orthologues and 22 paralogues. Biased expression in brain (RPKM 14.4), adrenal (RPKM 3.2) and 12 other tissues.

Summary

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]

LRRC4 Products(1)

mRNA	Protein	Name
NM_022143.5	NP_071426.1	leucine-rich repeat-containing protein 4 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21946559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC4 Protein Structure

LRR_5

LRR_8

I-set

0
100
200
300
400
500
600
653 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat-containing protein 4

brain tumor associated protein LRRC4

LRRC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LRRC4	Q9HBW1	NTNG1	Homo sapiens	Q9Y2I2	SPR	21946559
Intra	LRRC4	Q9HBW1	NTNG2	Homo sapiens	Q96CW9	Light Scattering	21946559
Intra	LRRC4	Q9HBW1	NTNG2	Homo sapiens	Q96CW9	X-Ray Diffraction	21946559
Intra	LRRC4	Q9HBW1	NTNG2	Homo sapiens	Q96CW9	SPR	21946559

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07818	LRRC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07821	LRRC4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07822	LRRC4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRRC4	VGNC	VGNC:74293
Bos taurus	LRRC4	VGNC	VGNC:31014
Canis familiaris	LRRC4	VGNC	VGNC:42797
Rattus norvegicus	LRRC4	RGD	RGD:1560026
Mus musculus	LRRC4	MGD	MGI:2182081
Felis catus	LRRC4	VGNC	VGNC:80614
Others	LRRC4	NCBI

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