2. Gene
  3. CENPK - centromere protein K Gene

CENPK - centromere protein K Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as P33; Solt; CENP-K; FKSG14; AF5alpha

Gene ID: 64105 | Gene type: protein coding

About CENPK

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:65,495,624-65,563,168 (from NCBI)

This gene has 17 transcripts (splice variants) and 197 orthologues. Broad expression in testis (RPKM 1.8), bone marrow (RPKM 1.7) and 19 other tissues.

Summary

CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

CENPK Products(5)

mRNA Protein Name
NM_001267038.2 NP_001253967.1 centromere protein K isoform 1
NM_001349367.2 NP_001336296.1 centromere protein K isoform 3
NM_001349368.2 NP_001336297.1 centromere protein K isoform 4
NM_001349369.2 NP_001336298.1 centromere protein K isoform 5
NM_022145.5 NP_071428.2 centromere protein K isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24981860 GOA
Cellular Component GO Annotation Evidence Reference Source
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPK Protein Structure

CENP-K

CENP-K: Centromere-associated protein K (2 - 269)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

centromere protein K

SoxLZ/Sox6-binding protein Solt

CENPK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CENPK Q9BS16 CENPH Homo sapiens Q9H3R5
Y2H Prey Pooling
25416956
Intra CENPK Q9BS16 CENPH Homo sapiens Q9H3R5
Validated Y2H
32296183
Intra CENPK Q9BS16 CENPI Homo sapiens Q92674
Anti Tag CoIP
33961781
Intra CENPK Q9BS16 CENPI Homo sapiens Q92674
TAP
24981860
Intra CENPK Q9BS16 PEX14 Homo sapiens O75381
Y2H Prey Pooling
32296183
Intra CENPK Q9BS16 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra CENPK Q9BS16 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02483 CENPK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CENPK VGNC VGNC:60756
Canis familiaris CENPK VGNC VGNC:39106
Rattus norvegicus CENPK RGD RGD:1310461
Bos taurus CENPK VGNC VGNC:27179
Macaca mulatta CENPK VGNC VGNC:71136
Mus musculus CENPK MGD MGI:1926210