2. Gene
  3. ATL2 - atlastin GTPase 2 Gene

ATL2 - atlastin GTPase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as aip-2; ARL3IP2; ARL6IP2; atlastin2

Gene ID: 64225 | Gene type: protein coding

About ATL2

Cytogenetic location: 2p22.2-p22.1 Genomic coordinates (GRCh38): 2:38,293,954-38,378,584 (from NCBI)

This gene has 18 transcripts (splice variants), 297 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 13.5), skin (RPKM 9.8) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Located in endoplasmic reticulum tubular network membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATL2 Products(10)

mRNA Protein Name
NM_001135673.4 NP_001129145.1 atlastin-2 isoform 2
NM_001308076.1 NP_001295005.1 atlastin-2 isoform 3
NM_001330458.2 NP_001317387.1 atlastin-2 isoform 4
NM_001330459.1 NP_001317388.1 atlastin-2 isoform 5
NM_001330460.1 NP_001317389.1 atlastin-2 isoform 6
NM_001330461.2 NP_001317390.1 atlastin-2 isoform 6
NM_001330462.1 NP_001317391.1 atlastin-2 isoform 7
NM_001330463.2 NP_001317392.1 atlastin-2 isoform 8
NM_001330464.2 NP_001317393.1 atlastin-2 isoform 9
NM_022374.5 NP_071769.2 atlastin-2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
18270207 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
18270207 GOA
involved in endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
18270207 GOA
NOT involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
18270207 GOA
involved in endoplasmic reticulum tubular network membrane organization IMP
IMP: Inferred from mutant phenotype
27619977 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
18270207 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18270207 GOA
located in endoplasmic reticulum tubular network membrane IDA
IDA: Inferred from direct assay
27619977 GOA
located in membrane IDA
IDA: Inferred from direct assay
18270207 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATL2 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (70 - 341)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (344 - 464)

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  • 583 a.a.
Protein Preferred Names Protein Names

atlastin-2

ADP-ribosylation factor-like protein 6-interacting protein 2

Related Diseases

Diseases Alias
Spastic Paraplegia 3a

Spg3a

Atl1-Hsp

Spastic Paraplegia Type 3a

Spastic Paraplegia 3

Spastic Paraplegia 3, Autosomal Dominant
Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia

Atll

Adult T-Cell Leukaemia

Adult T-Cell Leukaemia/Lymphoma

Adult T-Cell Lymphoma

T Cell Leukemia Lymphoma Adult

Leukemia-Lymphoma, Adult T-Cell

Leukemia, T-Cell

Adult T-Cell Lymphoma/Leukemia
Spondylolysis

Acquired Spondylolysis
Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I

Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

Hsan1e

Hsan1

Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

Hsn1e

Hsnie

Hereditary Sensory Neuropathy Type Ie

Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

Hereditary Sensory And Autonomic Neuropathy Type Ie

Hereditary Sensory And Autonomic Neuropathy Type 1e

Hereditary Sensory Neuropathy With Hearing Loss And Dementia

Dnmt1-Complex Disorder

Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

Hsn Ie

Hereditary Sensory Autonomic Neuropathy, Type 1

Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Hereditary Sensory Neuropathy

Hereditary Sensory And Autonomic Neuropathy

Hereditary Sensory And Autonomic Neuropathies

Familial Dysautonomia, Type Ii

Hsan

Sensory Neuropathy Hereditary

Neuropathy, Sensory And Autonomic, Hereditary

Neuropathy, Sensory, Hereditary

Sensory Neuropathy, Hereditary

Charcot-Marie-Tooth Disease

Cmt - [Charcot-Marie-Tooth Disease]
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01158 ATL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATL2 VGNC VGNC:26266
Felis catus ATL2 VGNC VGNC:60009
Rattus norvegicus ATL2 RGD RGD:1305125
Mus musculus ATL2 MGD MGI:1929492
Canis familiaris ATL2 VGNC VGNC:38231
Macaca mulatta ATL2 VGNC VGNC:70116
Others ATL2 NCBI