IKZF5 - IKAROS family zinc finger 5 Gene

Homo sapiens

Also known as THC7; PEGASUS; ZNFN1A5

Gene ID: 64376 | Gene type: protein coding

About IKZF5

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:122,990,806-123,008,795 (from NCBI)

This gene has 5 transcripts (splice variants), 265 orthologues, 38 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.4), testis (RPKM 7.5) and 25 other tissues.

Summary

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

IKZF5 Products(10)

mRNA	Protein	Name
NM_001271840.1	NP_001258769.1	zinc finger protein Pegasus isoform 1
NM_001372123.1	NP_001359052.1	zinc finger protein Pegasus isoform 1
NM_001372124.1	NP_001359053.1	zinc finger protein Pegasus isoform 2
NM_001372125.1	NP_001359054.1	zinc finger protein Pegasus isoform 1
NM_001372126.1	NP_001359055.1	zinc finger protein Pegasus isoform 1
NM_001372127.1	NP_001359056.1	zinc finger protein Pegasus isoform 1
NM_001372128.1	NP_001359057.1	zinc finger protein Pegasus isoform 1
NM_001372129.1	NP_001359058.1	zinc finger protein Pegasus isoform 2
NM_001372130.1	NP_001359059.1	zinc finger protein Pegasus isoform 2
NM_001372131.1	NP_001359060.1	zinc finger protein Pegasus isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10978333	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10978333	GOA
enables chromatin binding	IMP IMP: Inferred from mutant phenotype	31217188	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15491138	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15491138	GOA
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	15491138	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10978333	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IMP IMP: Inferred from mutant phenotype	31217188	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15491138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IKZF5 Protein Structure

zf-H2C2_2

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

zinc finger protein Pegasus

zinc finger protein, subfamily 1A, 5 (Pegasus)

IKZF5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IKZF5	Q9H5V7	IKZF3	Homo sapiens	Q9UKT9	Anti Tag CoIP	28514442
Intra	IKZF5	Q9H5V7	IKZF3	Homo sapiens	Q9UKT9	Anti Tag CoIP	33961781
Intra	IKZF5	Q9H5V7	IKZF3	Homo sapiens	Q9UKT9	Anti Tag CoIP	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Thrombocytopenia 7

THC7	Thrombocytopenia, Autosomal Dominant, 7

Autosomal Thrombocytopenia With Normal Platelets

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Pseudo-Von Willebrand Disease

Bdplt3	Von Willebrand Disease, Platelet-Type
VWDP	Platelet-Type Bleeding Disorder 3
Platelet Type-Von Willebrand Disease	Pt-Vwd
Von Willebrand Disease Platelet-Type	Von Willebrand Disease, Platelet Type
Pseudo Von Willebrand Disease	Bleeding Disorder, Platelet-Type, 3
Pseudo-Von Willebrand Disease Type 2b	Bleeding Disorder Platelet-Type 3
Pseudo-Vwd

Radioulnar Synostosis

Radio-Ulnar Synostosis Type 1

Amegakaryocytic Thrombocytopenia, Congenital

Congenital Amegakaryocytic Thrombocytopenia	CAMT
Thrombocytopenia, Congenital Amegakaryocytic	Congenital Amegakaryocytic Thrombocytopenic Purpura
Thrombocytopenia Congenital Amegakaryocytic	Thrombocytopenia, Amegakaryocytic, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06669	IKZF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IKZF5	MGD	MGI:1914393
Canis familiaris	IKZF5	VGNC	VGNC:41927
Macaca mulatta	IKZF5	VGNC	VGNC:73590
Bos taurus	IKZF5	VGNC	VGNC:30106
Rattus norvegicus	IKZF5	RGD	RGD:1310965

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