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  3. AKTIP - AKT interacting protein Gene

AKTIP - AKT interacting protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FT1; FTS

Gene ID: 64400 | Gene type: protein coding

About AKTIP

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,491,040-53,504,412 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 23.1), brain (RPKM 22.1) and 25 other tissues.

Summary

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant Animals while homozygous mutants die in early development. This gene may play a role in Apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin Ligase domain of Other ubiquitin-conjugating Enzymes but lacks the conserved cysteine residue that enables those Enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

AKTIP Products(3)

mRNA Protein Name
NM_001012398.3 NP_001012398.1 AKT-interacting protein isoform 1
NM_001308325.2 NP_001295254.1 AKT-interacting protein isoform 2
NM_022476.4 NP_071921.1 AKT-interacting protein isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in lysosome organization IMP
IMP: Inferred from mutant phenotype
18799622 GOA
acts upstream of or within positive regulation of protein binding IDA
IDA: Inferred from direct assay
14749367 GOA
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
14749367 GOA
involved in protein localization to perinuclear region of cytoplasm IMP
IMP: Inferred from mutant phenotype
32073997 GOA
Cellular Component GO Annotation Evidence Reference Source
part of FHF complex IDA
IDA: Inferred from direct assay
18799622 GOA
part of HOPS complex IDA
IDA: Inferred from direct assay
18799622 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
14749367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKTIP Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (79 - 214)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

AKT-interacting protein

fused toes homolog

AKTIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AKTIP Q9H8T0 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra
AKTIP Q9H8T0 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
AKTIP Q9H8T0 HOOK3 Homo sapiens Q86VS8
Y2H
32073997
Intra
AKTIP Q9H8T0 HOOK3 Homo sapiens Q86VS8
Anti Tag CoIP
33961781
Intra
AKTIP Q9H8T0 HOOK3 Homo sapiens Q86VS8
Y2H Fragment Pooling
23414517
Intra
AKTIP Q9H8T0 FHIP1A Homo sapiens Q05DH4
Y2H
32073997
Intra
AKTIP Q9H8T0 FHIP1A Homo sapiens Q05DH4
Anti Tag CoIP
33961781
Intra
AKTIP Q9H8T0 TRIM32 Homo sapiens Q13049
Anti Tag CoIP
33961781
Intra
AKTIP Q9H8T0 HOOK2 Homo sapiens Q96ED9
Anti Tag CoIP
33961781
Intra
AKTIP Q9H8T0 HOOK2 Homo sapiens Q96ED9
Y2H
32073997
Intra
AKTIP Q9H8T0 HOOK1 Homo sapiens Q9UJC3
Anti Tag CoIP
33961781
Intra
AKTIP Q9H8T0 HOOK1 Homo sapiens Q9UJC3
Y2H Prey Pooling
32296183
Intra
AKTIP Q9H8T0 HOOK1 Homo sapiens Q9UJC3
Y2H Array
32296183
Intra
AKTIP Q9H8T0 HOOK1 Homo sapiens Q9UJC3
Anti Bait CoIP
17353931
Intra
AKTIP Q9H8T0 HOOK1 Homo sapiens Q9UJC3
Validated Y2H
25416956
Intra
AKTIP Q9H8T0 HOOK1 Homo sapiens Q9UJC3
Y2H Prey Pooling
25416956
Intra
AKTIP Q9H8T0 HOOK1 Homo sapiens Q9UJC3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Achilles Bursitis

Achilles Bursitis Or Tendinitis

Capped Hock

Haglund'S Deformity

Haglund'S Disease

Osteochondritis Of The Talus
Pulmonary Talcosis

Pneumoconiosis Due To Talc

Talc Pneumoconiosis

Talcosis
Discrete Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00552 AKTIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AKTIP VGNC VGNC:37774
Mus musculus AKTIP MGD MGI:3693832
Macaca mulatta AKTIP VGNC VGNC:69619
Bos taurus AKTIP VGNC VGNC:25801
Rattus norvegicus AKTIP RGD RGD:1311170
Felis catus AKTIP VGNC VGNC:59730