HOOK2 - hook microtubule tethering protein 2 Gene

Homo sapiens

Also known as HK2

Gene ID: 29911 | Gene type: protein coding

About HOOK2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,763,003-12,792,350 (from NCBI)

This gene has 25 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 18.1), duodenum (RPKM 14.2) and 24 other tissues.

Summary

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

HOOK2 Products(9)

mRNA	Protein	Name
NM_001100176.2	NP_001093646.1	protein Hook homolog 2 isoform 2
NM_001400041.1	NP_001386970.1	protein Hook homolog 2 isoform 3
NM_001400043.1	NP_001386972.1	protein Hook homolog 2 isoform 4
NM_001400044.1	NP_001386973.1	protein Hook homolog 2 isoform 4
NM_001400045.1	NP_001386974.1	protein Hook homolog 2 isoform 4
NM_001400046.1	NP_001386975.1	protein Hook homolog 2 isoform 4
NM_001400047.1	NP_001386976.1	protein Hook homolog 2 isoform 4
NM_001400048.1	NP_001386977.1	protein Hook homolog 2 isoform 4
NM_013312.3	NP_037444.2	protein Hook homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18799622	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in lysosome organization	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in protein localization to perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	32073997	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FHF complex	IDA IDA: Inferred from direct assay	18799622	GOA
part of HOPS complex	IDA IDA: Inferred from direct assay	18799622	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17140400	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	32073997	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOOK2 Protein Structure

HOOK

0
200
400
600
719 a.a.

Protein Preferred Names

Protein Names

protein Hook homolog 2

h-hook2

HOOK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOOK2	Q96ED9	UTP14C	Homo sapiens	Q08E77	Y2H Prey Pooling	25416956
Intra	HOOK2	Q96ED9	UTP14C	Homo sapiens	Q08E77	Validated Y2H	25416956
Intra	HOOK2	Q96ED9	UTP14C	Homo sapiens	Q08E77	Y2H Array	25416956
Intra	HOOK2	Q96ED9	SUV39H1	Homo sapiens	O43463	Y2H	21516116
Intra	HOOK2	Q96ED9	SUV39H1	Homo sapiens	O43463	Y2H Prey Pooling	25416956
Intra	HOOK2	Q96ED9	SUV39H1	Homo sapiens	O43463	Validated Y2H	25416956
Intra	HOOK2	Q96ED9	SUV39H1	Homo sapiens	O43463	Y2H Array	25416956
Intra	HOOK2	Q96ED9	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
Intra	HOOK2	Q96ED9	CWF19L2	Homo sapiens	Q2TBE0	Y2H Prey Pooling	25416956
Intra	HOOK2	Q96ED9	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	25416956
Intra	HOOK2	Q96ED9	CWF19L2	Homo sapiens	Q2TBE0	Y2H Array	25416956
Intra	HOOK2	Q96ED9	FHIP2A	Homo sapiens	Q5W0V3	Anti Tag CoIP	34882091
Intra	HOOK2	Q96ED9	FHIP2A	Homo sapiens	Q5W0V3	BioID	34882091
Intra	HOOK2	Q96ED9	AKTIP	Homo sapiens	Q9H8T0	Y2H Array	31515488
Intra	HOOK2	Q96ED9	AKTIP	Homo sapiens	Q9H8T0	BioID	34882091
Intra	HOOK2	Q96ED9	AKTIP	Homo sapiens	Q9H8T0	Y2H Pooling	16189514
Intra	HOOK2	Q96ED9	AKTIP	Homo sapiens	Q9H8T0	Y2H Fragment Pooling	23414517
Intra	HOOK2	Q96ED9	AKTIP	Homo sapiens	Q9H8T0	Y2H	32073997
Intra	HOOK2	Q96ED9	KANSL1	Homo sapiens	Q7Z3B3	Y2H Prey Pooling	25416956
Intra	HOOK2	Q96ED9	KANSL1	Homo sapiens	Q7Z3B3	Y2H Array	25416956
Intra	HOOK2	Q96ED9	ZC2HC1C	Homo sapiens	Q53FD0	Y2H Prey Pooling	25416956
Intra	HOOK2	Q96ED9	ZC2HC1C	Homo sapiens	Q53FD0	Y2H Array	25416956
Intra	HOOK2	Q96ED9	ZC2HC1C	Homo sapiens	Q53FD0	Validated Y2H	25416956
Intra	HOOK2	Q96ED9	CCDC33	Homo sapiens	Q8N5R6	Y2H Pooling	16189514
Intra	HOOK2	Q96ED9	ANKRD36BP1	Homo sapiens	Q96IX9	Y2H Prey Pooling	25416956
Intra	HOOK2	Q96ED9	DUSP13B	Homo sapiens	Q9UII6	Validated Y2H	25416956
Intra	HOOK2	Q96ED9	DUSP13B	Homo sapiens	Q9UII6	Y2H Array	25416956
Intra	HOOK2	Q96ED9	DUSP13B	Homo sapiens	Q9UII6	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06288	HOOK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HOOK2	RGD	RGD:1310171
Canis familiaris	HOOK2	VGNC	VGNC:41741
Felis catus	HOOK2	VGNC	VGNC:62833
Macaca mulatta	HOOK2	VGNC	VGNC:73425
Mus musculus	HOOK2	MGD	MGI:2181664
Bos taurus	HOOK2	VGNC	VGNC:29906

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