2. Gene
  3. HOOK1 - hook microtubule tethering protein 1 Gene

HOOK1 - hook microtubule tethering protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HK1

Gene ID: 51361 | Gene type: protein coding

About HOOK1

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,814,949-59,876,322 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 5 paralogues. Broad expression in testis (RPKM 15.7), colon (RPKM 10.0) and 21 other tissues.

Summary

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule Cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

HOOK1 Products(1)

mRNA Protein Name
NM_015888.6 NP_056972.1 protein Hook homolog 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18799622 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15471887 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
32073997 GOA
Biological Process GO Annotation Evidence Reference Source
involved in early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in lysosome organization IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in protein localization to perinuclear region of cytoplasm IMP
IMP: Inferred from mutant phenotype
32073997 GOA
Cellular Component GO Annotation Evidence Reference Source
part of FHF complex IDA
IDA: Inferred from direct assay
18799622 GOA
part of HOPS complex IDA
IDA: Inferred from direct assay
18799622 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15471887 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOOK1 Protein Structure

HOOK

HOOK: HOOK protein (9 - 727)

  • 0
  • 200
  • 400
  • 600
  • 728 a.a.
Protein Preferred Names Protein Names

protein Hook homolog 1

h-hook1

HOOK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
HOOK1 Q9UJC3 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
HOOK1 Q9UJC3 ZNF80 Homo sapiens P51504
Y2H Prey Pooling
32296183
Intra
HOOK1 Q9UJC3 ZNF80 Homo sapiens P51504
Y2H Array
32296183
Intra
HOOK1 Q9UJC3 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
HOOK1 Q9UJC3 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
HOOK1 Q9UJC3 HOOK3 Homo sapiens Q86VS8
Y2H
32073997
Intra
HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Y2H Prey Pooling
32296183
Intra
HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Y2H Array
31515488
Intra
HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Validated Y2H
25416956
Intra
HOOK1 Q9UJC3 CDK4 Homo sapiens P11802
Y2H Array
32296183
Intra
HOOK1 Q9UJC3 TBC1D7 Homo sapiens Q9P0N9
Y2H Array
31515488
Intra
HOOK1 Q9UJC3 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
25416956
Intra
HOOK1 Q9UJC3 TBC1D7 Homo sapiens Q9P0N9
Y2H Array
25416956
Intra
HOOK1 Q9UJC3 NCOR1 Homo sapiens O75376
Validated Y2H
32814053
Intra
HOOK1 Q9UJC3 NCOR1 Homo sapiens O75376
Y2H Array
32814053
Intra
HOOK1 Q9UJC3 NCOR1 Homo sapiens O75376
Y2H Pooling
32814053
Intra
HOOK1 Q9UJC3 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
HOOK1 Q9UJC3 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
HOOK1 Q9UJC3 CDC5L Homo sapiens Q99459
Y2H
17043677
Intra
HOOK1 Q9UJC3 ZNF785 Homo sapiens A8K8V0
Y2H Prey Pooling
25416956
Intra
HOOK1 Q9UJC3 ZNF785 Homo sapiens A8K8V0
Validated Y2H
25416956
Intra
HOOK1 Q9UJC3 ZNF785 Homo sapiens A8K8V0
Y2H Array
25416956
Intra
HOOK1 Q9UJC3 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra
HOOK1 Q9UJC3 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra
HOOK1 Q9UJC3 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
HOOK1 Q9UJC3 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
HOOK1 Q9UJC3 SYCE1 Homo sapiens Q8N0S2
Validated Y2H
25416956
Intra
HOOK1 Q9UJC3 AKTIP Homo sapiens Q9H8T0
Y2H Array
25416956
Intra
HOOK1 Q9UJC3 AKTIP Homo sapiens Q9H8T0
Y2H
32073997
Intra
HOOK1 Q9UJC3 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
HOOK1 Q9UJC3 USP2 Homo sapiens O75604
Y2H Prey Pooling
25416956
Intra
HOOK1 Q9UJC3 BSG Homo sapiens P35613
Anti Bait CoIP
29423001
Intra
HOOK1 Q9UJC3 BSG Homo sapiens P35613
Confocal
29423001
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 16

SPGF16

Acephalic Spermatozoa Syndrome

Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome
Metanephric Adenoma
Renal Adenoma

Renal Cell Adenoma
Cranioectodermal Dysplasia 1

Sensenbrenner Syndrome

CED1

Levin Syndrome I

Cranio-Ectodermal Dysplasia

Dysplasia, Cranioectodermal, Type 1

Cranioectodermal Dysplasia
Ceroid Lipofuscinosis, Neuronal, 3

Batten Disease

Juvenile Neuronal Ceroid Lipofuscinosis

Neuronal Ceroid Lipofuscinosis 3

CLN3

Jncl

Spielmeyer-Vogt Disease

Vogt-Spielmeyer Disease

Spielmeyer-Sjogren Disease

Cln3 Disease

Neuronal Ceroid Lipofuscinosis, Juvenile

Cln3 Disease, Juvenile

Spielmeyer Sjogren Disease

Vogt Spielmeyer Disease

Batten-Mayou Disease

Batten-Spielmeyer-Vogt Disease

Cln3-Related Neuronal Ceroid-Lipofuscinosis

Juvenile Batten Disease

Juvenile Cerebroretinal Degeneration

Classic Juvenile Ncl

Classic Juvenile Neuronal Ceroid Lipofuscinosis

Juvenile Ncl

Lipofuscinosis, Ceroid, Neuronal, Type 3
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-168619 DNA crosslinker 6 Inhibitor / Unkown
HY-RS06287 HOOK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HOOK1 MGD MGI:1925213
Rattus norvegicus HOOK1 RGD RGD:1309987
Canis familiaris HOOK1 VGNC VGNC:41740
Macaca mulatta HOOK1 VGNC VGNC:73424
Bos taurus HOOK1 VGNC VGNC:29905
Felis catus HOOK1 VGNC VGNC:62832