METTL17 - methyltransferase like 17 Gene

Homo sapiens

Also known as METT11D1

Gene ID: 64745 | Gene type: protein coding

About METTL17

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,989,980-20,997,035 (from NCBI)

This gene has 25 transcripts (splice variants), 180 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 22.3), lymph node (RPKM 19.6) and 25 other tissues.

Summary

Predicted to enable S-adenosyl-L-methionine binding activity and mitochondrial ribosome binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

METTL17 Products(2)

mRNA	Protein	Name
NM_001029991.2	NP_001025162.1	methyltransferase-like protein 17, mitochondrial isoform 1 precursor
NM_022734.3	NP_073571.1	methyltransferase-like protein 17, mitochondrial isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 4 iron, 4 sulfur cluster binding	IDA IDA: Inferred from direct assay	36482135	GOA
NOT enables methyltransferase activity	IDA IDA: Inferred from direct assay	38234605	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial small ribosomal subunit assembly	IDA IDA: Inferred from direct assay	36482135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL17 Protein Structure

Rsm22

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

methyltransferase-like protein 17, mitochondrial

false p73 target gene protein

METTL17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	METTL17	Q9H7H0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	METTL17	Q9H7H0	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	26871637
Intra	METTL17	Q9H7H0	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	26871637
Intra	METTL17	Q9H7H0	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	26871637
Intra	METTL17	Q9H7H0	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	METTL17	Q9H7H0	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	METTL17	Q9H7H0	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	26871637
Intra	METTL17	Q9H7H0	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	26871637
Intra	METTL17	Q9H7H0	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	METTL17	Q9H7H0	PNMA1	Homo sapiens	Q8ND90	Y2H Array	26871637
Intra	METTL17	Q9H7H0	SF3B4	Homo sapiens	Q15427	Y2H Array	25416956
Intra	METTL17	Q9H7H0	TRAF1	Homo sapiens	Q13077	Validated Y2H	26871637
Intra	METTL17	Q9H7H0	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	26871637
Intra	METTL17	Q9H7H0	TRAF1	Homo sapiens	Q13077	Y2H Array	26871637
Intra	METTL17	Q9H7H0	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	METTL17	Q9H7H0	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	26871637
Intra	METTL17	Q9H7H0	MDFI	Homo sapiens	Q99750	Validated Y2H	26871637
Intra	METTL17	Q9H7H0	MDFI	Homo sapiens	Q99750	Y2H Array	26871637
Intra	METTL17	Q9H7H0	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	METTL17	Q9H7H0	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	26871637
Intra	METTL17	Q9H7H0	CALCOCO2	Homo sapiens	Q13137	Y2H Array	26871637
Intra	METTL17	Q9H7H0	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	METTL17	Q9H7H0	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	26871637
Intra	METTL17	Q9H7H0	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	26871637
Intra	METTL17	Q9H7H0	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	26871637
Intra	METTL17	Q9H7H0	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	METTL17	Q9H7H0	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	26871637
Intra	METTL17	Q9H7H0	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	METTL17	Q9H7H0	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	METTL17	Q9H7H0	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	METTL17	Q9H7H0	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08358	METTL17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	METTL17	MGD	MGI:1098577
Canis familiaris	METTL17	VGNC	VGNC:106604
Macaca mulatta	METTL17	VGNC	VGNC:81473
Felis catus	METTL17	VGNC	VGNC:80913
Bos taurus	METTL17	VGNC	VGNC:55124
Rattus norvegicus	METTL17	RGD	RGD:1559895

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