SLC22A1 - solute carrier family 22 member 1 Gene

Homo sapiens

Also known as OCT1; HOCT1; oct1_cds

Gene ID: 6580 | Gene type: protein coding

About SLC22A1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,121,815-160,158,718 (from NCBI)

This gene has 7 transcripts (splice variants), 495 orthologues and 22 paralogues. Restricted expression toward liver (RPKM 121.5).

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

SLC22A1 Products(2)

mRNA	Protein	Name
NM_003057.3	NP_003048.1	solute carrier family 22 member 1 isoform a
NM_153187.2	NP_694857.1	solute carrier family 22 member 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15817714	GOA
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	9260930	GOA
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	12439218	GOA
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11907186	GOA
enables organic cation transmembrane transporter activity	EXP EXP: Inferred from Experiment	19141712	GOA
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	9260930	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: Inferred from direct assay	11907186	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11543633	GOA
enables putrescine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21128598	GOA
enables pyrimidine nucleoside transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	GOA
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	23567998	GOA
enables toxin transmembrane transporter activity	IDA IDA: Inferred from direct assay	22806583	GOA
enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	9260930	GOA
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetylcholine transport	IDA IDA: Inferred from direct assay	15817714	GOA
involved in cellular detoxification	IDA IDA: Inferred from direct assay	22806583	GOA
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	20477935	GOA
involved in dopamine transport	IDA IDA: Inferred from direct assay	35469921	GOA
involved in dopamine uptake	IDA IDA: Inferred from direct assay	24688079	GOA
involved in epinephrine transport	IDA IDA: Inferred from direct assay	35469921	GOA
involved in monoamine transport	IDA IDA: Inferred from direct assay	35469921	GOA
involved in neurotransmitter transport	IDA IDA: Inferred from direct assay	24688079	GOA
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	24688079	GOA
involved in organic cation transport	IDA IDA: Inferred from direct assay	22806583	GOA
involved in prostaglandin transport	IDA IDA: Inferred from direct assay	11907186	GOA
involved in putrescine transport	IDA IDA: Inferred from direct assay	21128598	GOA
involved in quaternary ammonium group transport	IDA IDA: Inferred from direct assay	23567998	GOA
involved in serotonin transport	IDA IDA: Inferred from direct assay	12439218	GOA
involved in serotonin uptake	IDA IDA: Inferred from direct assay	24688079	GOA
involved in thiamine transmembrane transport	IDA IDA: Inferred from direct assay	24961373	GOA
involved in thiamine transport	IDA IDA: Inferred from direct assay	24961373	GOA
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	9260930	GOA
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	20477935	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15817714	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	35307651	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12719534	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	16263091	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A1 Protein Structure

Sugar_tr

0
100
200
300
400
500
554 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 1

organic cation transporter 1

SLC22A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC22A1	O15245	CERS2	Homo sapiens	Q96G23	Pull Down	11543633
Intra	SLC22A1	O15245	CERS2	Homo sapiens	Q96G23	Y2H	21988832
Intra	SLC22A1	O15245	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cholestasis

Obstruction Of Bile Duct	Bile Duct Obstruction
Bile Occlusion	Extrahepatic Biliary Obstruction
Extrahepatic Bile Duct Obstruction	Bile Stasis
Biliary Stasis	Obstructive Hyperbilirubinemia
Obstructed Jaundice	Bile Duct Obstructed
Bile Ductal Obstruction	Biliary Duct Obstruction
Obstructed Bile Ductal	Obstructed Biliary Duct
Obstructed Biliary Ductal	Jaundice Regurgitation
Obstructive Jaundice	Cholestatic Jaundice
Cholestatic Jaundice Syndrome

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome	17q23.1-Q23.2 Microdeletion Syndrome
Del(17)(Q23.1q23.2)	Monosomy 17q23.1q23.2
Monosomy 17q23.1-Q23.2

Diabetes Mellitus

Diabetes

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13061	SLC22A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC22A1	VGNC	VGNC:77417
Rattus norvegicus	SLC22A1	RGD	RGD:3224
Mus musculus	SLC22A1	MGD	MGI:108111
Bos taurus	SLC22A1	VGNC	VGNC:34719
Canis familiaris	SLC22A1	VGNC	VGNC:46270
Felis catus	SLC22A1	VGNC	VGNC:97629
Others	SLC22A1	NCBI

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