SMIM3 - small integral membrane protein 3 Gene

Homo sapiens

Also known as NID67; MST150; C5orf62

Gene ID: 85027 | Gene type: protein coding

About SMIM3

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,778,757-150,796,734 (from NCBI)

This gene has 2 transcripts (splice variants) and 108 orthologues. Broad expression in fat (RPKM 64.3), bone marrow (RPKM 21.5) and 18 other tissues.

Summary

Enables identical protein binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SMIM3 Products(1)

mRNA	Protein	Name
NM_032947.5	NP_116565.3	small integral membrane protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

small integral membrane protein 3

NGF-induced differentiation clone 67 protein

SMIM3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMIM3	Q9BZL3	LSMEM2	Homo sapiens	Q8N112	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	LSMEM2	Homo sapiens	Q8N112	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	TEX264	Homo sapiens	Q9Y6I9	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	SMIM3	Q9BZL3	TEX264	Homo sapiens	Q9Y6I9	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	SMIM3	Q9BZL3	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	SLC22A1	Homo sapiens	O15245	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	SLC22A1	Homo sapiens	O15245	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	ATP1B4	Homo sapiens	Q9UN42	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	ATP1B4	Homo sapiens	Q9UN42	Validated Y2H	32296183
Intra	SMIM3	Q9BZL3	ATP1B4	Homo sapiens	Q9UN42	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	SMIM3	Q9BZL3	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	LPAR6	Homo sapiens	P43657	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	LPAR6	Homo sapiens	P43657	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	SMIM3	Q9BZL3	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	SMIM3	Q9BZL3	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	SMIM3	Q9BZL3	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	MAL	Homo sapiens	P21145	Validated Y2H	25416956
Intra	SMIM3	Q9BZL3	EMP1	Homo sapiens	P54849	Validated Y2H	25416956
Intra	SMIM3	Q9BZL3	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	25416956
Intra	SMIM3	Q9BZL3	SGCB	Homo sapiens	Q16585	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	SGCB	Homo sapiens	Q16585	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	ATP6V0C	Homo sapiens	P27449	Y2H Prey Pooling	25416956
Intra	SMIM3	Q9BZL3	ATP6V0C	Homo sapiens	P27449	Y2H Array	25416956
Intra	SMIM3	Q9BZL3	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	SMIM3	Q9BZL3	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	SMIM3	Q9BZL3	BSCL2	Homo sapiens	Q96G97	Y2H Prey Pooling	25416956
Intra	SMIM3	Q9BZL3	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SMIM3	Q9BZL3	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SMIM3	Q9BZL3	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	SMIM3	Q9BZL3	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183
Intra	SMIM3	Q9BZL3	SLC38A1	Homo sapiens	Q9H2H9	Y2H Array	32296183
Intra	SMIM3	Q9BZL3	SLC38A1	Homo sapiens	Q9H2H9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13437	SMIM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SMIM3	MGD	MGI:1917088
Canis familiaris	SMIM3	VGNC	VGNC:46562
Felis catus	SMIM3	VGNC	VGNC:102325
Bos taurus	SMIM3	VGNC	VGNC:35021
Rattus norvegicus	SMIM3	RGD	RGD:628864

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