Nde1 - nudE neurodevelopment protein 1 Gene

Mus musculus

Also known as Nude; mNudE; 2810027M15Rik

Gene ID: 67203 | Gene type: protein coding

About Nde1

Summary

Enables identical protein binding activity and microtubule binding activity. Involved in centrosome duplication and neuron migration. Acts upstream of or within microtubule nucleation; nervous system development; and vesicle transport along microtubule. Located in spindle pole centrosome and synapse. Is expressed in several structures, including body cavity or lining; brain; early conceptus; integumental system; and vertebral axis musculature. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nde1 Products(4)

mRNA	Protein	Name
NM_001114085.1	NP_001107557.1	nuclear distribution protein nudE homolog 1 isoform b
NM_001285503.1	NP_001272432.1	nuclear distribution protein nudE homolog 1 isoform c
NM_001285504.1	NP_001272433.1	nuclear distribution protein nudE homolog 1 isoform d
NM_023317.2	NP_075806.2	nuclear distribution protein nudE homolog 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15571978	MGI
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	15473967	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11163258	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome duplication	IMP IMP: Inferred from mutant phenotype	15473967	MGI
acts upstream of or within cerebral cortex development	IGI IGI: Inferred from genetic interaction	18469343	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15473967	MGI
acts upstream of or within microtubule nucleation	IDA IDA: Inferred from direct assay	11163258	MGI
involved in microtubule organizing center organization	IMP IMP: Inferred from mutant phenotype	11163258	MGI
acts upstream of or within neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15473967	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	11163258	MGI
acts upstream of or within vesicle transport along microtubule	IGI IGI: Inferred from genetic interaction	16107726	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	11163258	MGI
located in microtubule organizing center	IDA IDA: Inferred from direct assay	11163258	MGI
located in spindle	IDA IDA: Inferred from direct assay	15473967	MGI
located in spindle pole centrosome	IDA IDA: Inferred from direct assay	15473967	MGI
located in synapse	IDA IDA: Inferred from direct assay	18983980	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear distribution protein nudE homolog 1

nuclear distribution gene E homolog 1

Nde1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nde1	Q9CZA6	Cenpf	Mus musculus	Q155P7	Y2H	15939891
Intra	Nde1	Q9CZA6	Cenpf	Mus musculus	Q155P7	Y2H	11163258
Cross	Nde1	Q9CZA6	DYNC1I1	Homo sapiens	O14576	Anti Bait CoIP	19927128
Cross	Nde1	Q9CZA6	PAFAH1B1	Homo sapiens	P43034	Y2H	11163258
Cross	Nde1	Q9CZA6	PAFAH1B1	Homo sapiens	P43034	Anti Tag CoIP	11163258
Cross	Nde1	Q9CZA6	PAFAH1B1	Homo sapiens	P43034	TAP	20360068

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09106	NDE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nde1	NCBI	NCBI:54820

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