2. Gene
  3. DYNC1I1 - dynein cytoplasmic 1 intermediate chain 1 Gene

DYNC1I1 - dynein cytoplasmic 1 intermediate chain 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DNCI1; DNCIC1

Gene ID: 1780 | Gene type: protein coding

About DYNC1I1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,772,554-96,110,322 (from NCBI)

This gene has 12 transcripts (splice variants), 257 orthologues and 7 paralogues. Biased expression in brain (RPKM 14.7), adrenal (RPKM 3.3) and 4 other tissues.

Summary

Enables spectrin binding activity. Involved in vesicle transport along microtubule. Located in several cellular components, including kinetochore; recycling endosome; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

DYNC1I1 Products(5)

mRNA Protein Name
NM_001135556.2 NP_001129028.1 cytoplasmic dynein 1 intermediate chain 1 isoform b
NM_001135557.2 NP_001129029.1 cytoplasmic dynein 1 intermediate chain 1 isoform c
NM_001278421.2 NP_001265350.1 cytoplasmic dynein 1 intermediate chain 1 isoform d
NM_001278422.2 NP_001265351.1 cytoplasmic dynein 1 intermediate chain 1 isoform e
NM_004411.5 NP_004402.1 cytoplasmic dynein 1 intermediate chain 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14985359 GOA
enables spectrin binding IDA
IDA: Inferred from direct assay
23704327 GOA
Biological Process GO Annotation Evidence Reference Source
involved in vesicle transport along microtubule IMP
IMP: Inferred from mutant phenotype
24561039 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25540360 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
15121898 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
19229290 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25540360 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
24561039 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
19229290 GOA
located in vesicle IDA
IDA: Inferred from direct assay
20682791 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNC1I1 Protein Structure

Dynein_IC2

Dynein_IC2: Cytoplasmic dynein 1 intermediate chain 2 (142 - 173)

WD40

WD40: WD domain, G-beta repeat (479 - 517)

  • 0
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  • 400
  • 500
  • 600
  • 645 a.a.
Protein Preferred Names Protein Names

cytoplasmic dynein 1 intermediate chain 1

DH IC-1

DYNC1I1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DYNC1I1 O14576 BICD2 Homo sapiens Q8TD16
Anti Tag CoIP
23664119
Intra
DYNC1I1 O14576 FAM83D Homo sapiens Q9H4H8
Anti Tag CoIP
33961781
Intra
DYNC1I1 O14576 FAM83D Homo sapiens Q9H4H8
Y2H
21900206
Intra
DYNC1I1 O14576 DYNLRB1 Homo sapiens Q9NP97
Anti Tag CoIP
33961781
Intra
DYNC1I1 O14576 DYNLRB1 Homo sapiens Q9NP97
Y2H Pooling
16189514
Intra
DYNC1I1 O14576 DYNLL2 Homo sapiens Q96FJ2
Y2H Pooling
16189514
Intra
DYNC1I1 O14576 DYNLL2 Homo sapiens Q96FJ2
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Joubert Syndrome 31

JBTS31
Brugada Syndrome 9

BRGDA9

Brugada Syndrome, Type 9
Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive

Split Hand-Foot Malformation 1 With Sensorineural Hearing Loss

SHFM1D

Deafness, Congenital, With Split Hands And Feet

Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss

Congenital Deafness With Split Hands And Feet

Split Hand-Split Foot-Deafness Syndrome

Split Hand-Split Foot-Hearing Loss Syndrome

Congenital Deafness And Split Hands And Feet

Split-Hand/Foot Malformation, Type 1 With Sensorineural Hearing Loss

Split-Hand-Foot Malformation With Sensorineural Hearing Loss
Paranoid Personality Disorder
Immunodeficiency 50

Combined Immunodeficiency Due To Moesin Deficiency

IMD50

Immunodeficiency 50, X-Linked Recessive

Cid Due To Moesin Deficiency

Msn-Related Combined Immunodeficiency

X-Linked Moesin-Associated Immunodeficiency

Immunodeficiency 50 X Linked Recessive
Split-Hand/Foot Malformation 4

SHFM4

Split Hand-Foot Malformation 4

Split-Hand/Foot Malformation, Type 4
Citrullinemia, Type Ii, Neonatal-Onset

NICCD

Citrin Deficiency

Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency

Citrullinemia, Type Ii, Neonatal-Onset, With Or Without Failure To Thrive And Dyslipidemia

Cholestasis, Neonatal Intrahepatic, Caused By Citrin Deficiency

Neonatal-Onset Type Ii Citrullinemia

Neonatal Intrahepatic Cholestasis Caused By Citrin Deficiency

Neonatal-Onset Citrullinemia Type 2

Neonatal-Onset Citrullinemia Type Ii

Neonatal-Onset Type 2 Citrullinemia

Adult-Onset Citrullinemia Type 2
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 3

EEC3

Eec Syndrome 3

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome, Type 3
Split Hand-Foot Malformation

Ectrodactyly

Split-Hand/Foot Malformation

Lobster-Claw Deformity

Split-Hand Deformity

Split Hand Foot Malformation

Shfm

Split Hand Foot Deformity

Split Hand Foot Deformity 1
Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis

Urbach-Wiethe Disease

Hyalinosis Cutis Et Mucosae

Lipid Proteinosis

Lipoproteinosis

Urbach Wiethe Disease

Lipoglycoproteinosis

Lipoidosis Cutis Et Mucosae

Lipoidproteinosis

Urbach-Wiethe Lipoid Proteinosis

Urbach-Wiethe Syndrome

LIP

Proteinosis Lipoid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04083 DYNC1I1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DYNC1I1 VGNC VGNC:71952
Rattus norvegicus DYNC1I1 RGD RGD:2512
Bos taurus DYNC1I1 VGNC VGNC:28270
Canis familiaris DYNC1I1 VGNC VGNC:40144
Felis catus DYNC1I1 VGNC VGNC:61676
Mus musculus DYNC1I1 MGD MGI:107743