SULT2B1 - sulfotransferase family 2B member 1 Gene

Homo sapiens

Also known as HSST2; ARCI14

Gene ID: 6820 | Gene type: protein coding

About SULT2B1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,552,172-48,599,427 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in esophagus (RPKM 55.8), skin (RPKM 46.5) and 4 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

SULT2B1 Products(2)

mRNA	Protein	Name
NM_004605.2	NP_004596.2	sulfotransferase 2B1 isoform a
NM_177973.2	NP_814444.1	sulfotransferase 2B1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholesterol binding	IDA IDA: Inferred from direct assay	12923182	GOA
enables nucleic acid binding	IMP IMP: Inferred from mutant phenotype	12923182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables small molecule binding	EXP EXP: Inferred from Experiment	12923182	GOA
enables steroid hormone binding	IMP IMP: Inferred from mutant phenotype	12923182	GOA
enables steroid sulfotransferase activity	IDA IDA: Inferred from direct assay	9799594	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	12923182	GOA
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	28575648	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	28575648	GOA
involved in positive regulation of epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	28575648	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	9799594	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	28575648	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT2B1 Protein Structure

Sulfotransfer_1

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

sulfotransferase 2B1

ST2B1

Recombinant SULT2B1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71011	SULT2B1 Protein, Human (311a.a, His)	O00204-1 (M1-E311)	≥95%
HY-P76666	SULT2B1 Protein, Human (364a.a, His)	O00204-1 (D2-S365)	≥95%

Related Diseases

Diseases

Alias

Ichthyosis, Congenital, Autosomal Recessive 14

ARCI14

Autosomal Recessive Congenital Ichthyosis 14

Ichthyosis, Congenital, Autosomal Recessive 1

Collodion Fetus	Autosomal Recessive Congenital Ichthyosis 1
ARCI1	Ichthyosis Congenita
Lamellar Exfoliation Of Newborn	Desquamation Of Newborn
Ichthyosis Congenita Ii	Shcb
Icr2	Bathing Suit Ichthyosis
Li1	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive 1, With Bathing Suit Distribution	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 1, Formerly	Li1, Formerly
Ichthyosis Lamellar 1	Lamellar Ichthyosis, Type 1
Bsi	Autosomal Recessive Congenital Ichthyosis 1 With Bathing Suit Distribution
Autosomal Recessive Congenital Ichthyosis Tgm1-Related	Lamellar Ichthyosis 1
Non-Erythrodermic Ichthyosis	Ichthyosis, Congenital, Autosomal Recessive, Type 1
Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 2

Autosomal Recessive Congenital Ichthyosis 2	ARCI2
Ncie1	Ichthyosiform Erythroderma, Congenital
Collodion Baby, Self-Healing	Ichthyosiform Erythroderma, Nonbullous Congenital, 1, Formerly
Ncie1, Formerly	Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form, Formerly
Brocq Congenital Ichthyosiform Erythroderma Nonbullous Form	Nonbullous Congenital Ichthyosiform Erythroderma 1
Cie	Ichthyosiform Erythroderma Brocq Congenital Non-Bullous Form
Iecn1	Non-Bullous Congenital Ichthyosiform Erythroderma Type 1
Self-Healing Collodion Baby	Ichthyosis, Congenital, Autosomal Recessive, Type 2
Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis	Autosomal Recessive Congenital Ichthyosis 4b
Hi	Harlequin Fetus
ARCI4B	Ichthyosis Congenita, Harlequin Fetus Type
Harlequin Type Ichthyosis	'Harlequin Fetus'
Harlequin Type Ichthyosis Congenita	Harlequin Type Ichthyosis Fetalis
Harlequin Baby Syndrome	Ichthyosis Congenita, Harlequin Type
Ichthyosis Fetalis, Harlequin Type	Ichthyosis Congenita Harlequin Fetus Type
Ichthyosis, Harlequin	Ichthyosis, Congenital, Autosomal Recessive, Type 4b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14021	SULT2B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SULT2B1	VGNC	VGNC:65837
Rattus norvegicus	SULT2B1	RGD	RGD:1308882
Mus musculus	SULT2B1	MGD	MGI:1926342
Canis familiaris	SULT2B1	VGNC	VGNC:46979
Bos taurus	SULT2B1	VGNC	VGNC:35468
Others	SULT2B1	NCBI

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