2. Gene
  3. Sirt5 - sirtuin 5 Gene

Sirt5 - sirtuin 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 0610012J09Rik; 1500032M05Rik

Gene ID: 68346 | Gene type: protein coding

About Sirt5

Chromosome 13: 43,518,972-43,548,679 forward strand.GRCm39:CM001006.3

This gene has 11 transcripts (splice variants), 265 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues.

Summary

Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of Succinate Dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (Sirtuin 5). [provided by Alliance of Genome Resources, Apr 2022]

Sirt5 Products(1)

mRNA Protein Name
NM_178848.3 NP_849179.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial

Sirt5 Protein Structure

SIRT5_Af1_CobB

SIRT5_Af1_CobB: cd01412 (50 - 300)

  • 0
  • 100
  • 200
  • 310 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacylase sirtuin-5, mitochondrial

NAD-dependent deacetylase sirtuin-5

NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0879A Suramin sodium salt Inhibitor 99.48% Yes
HY-B0879 Suramin Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-146387 SIRT5 inhibitor 3 Inhibitor ≥98.0% Unkown
HY-145651 Et-29 Inhibitor 99.89% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown
HY-152214 SIRT5 inhibitor 5 Inhibitor / Unkown
HY-146386 SIRT5 inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt5 NCBI NCBI:23408