VAMP7 - vesicle associated membrane protein 7 Gene

Homo sapiens

Also known as SYBL1; TIVAMP; VAMP-7; TI-VAMP

Gene ID: 6845 | Gene type: protein coding

About VAMP7

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,881,345-155,943,769 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 18.0), kidney (RPKM 17.3) and 25 other tissues.

Summary

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

VAMP7 Products(3)

mRNA	Protein	Name
NM_001145149.3	NP_001138621.1	vesicle-associated membrane protein 7 isoform 2
NM_001185183.2	NP_001172112.1	vesicle-associated membrane protein 7 isoform 3
NM_005638.6	NP_005629.1	vesicle-associated membrane protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16354670	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	23217709	GOA
involved in endosome to lysosome transport	IDA IDA: Inferred from direct assay	10888671	GOA
involved in eosinophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
involved in natural killer cell degranulation	IMP IMP: Inferred from mutant phenotype	18042464	GOA
involved in neutrophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
involved in positive regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	18253931	GOA
involved in vesicle fusion	IDA IDA: Inferred from direct assay	10888671	GOA
involved in vesicle-mediated transport	IDA IDA: Inferred from direct assay	10888671	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	18253931	GOA
located in azurophil granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18253931	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	22589474	GOA
located in membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18253931	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	22589474	GOA
located in pseudopodium	IDA IDA: Inferred from direct assay	22589474	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	18042464	GOA
located in secretory granule membrane	IDA IDA: Inferred from direct assay	16677249	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19745841	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP7 Protein Structure

Longin

Synaptobrevin

0
100
200
220 a.a.

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 7

synaptobrevin-like 1

Related Diseases

Diseases

Alias

Tetanus

Lockjaw	Clostridial Tetanus
Infection Due To Clostridium Tetani	Lock-Jaw

46,Xy Partial Gonadal Dysgenesis

46,Xy Pgd

46,Xy Partial Testicular Dysgenesis

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Deafness, Y-Linked 2

DFNY2

Y-Linked Deafness 2

Mesenteric Lymphadenitis

Mesenteric Adenitis

Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome

Cednik Syndrome	CEDNIK
Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome	Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro
Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome	Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma	Neurocutaneous Syndromes

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15598	VAMP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VAMP7	VGNC	VGNC:48226
Felis catus	VAMP7	VGNC	VGNC:66913
Bos taurus	VAMP7	VGNC	VGNC:107020
Macaca mulatta	VAMP7	VGNC	VGNC:78558
Rattus norvegicus	VAMP7	RGD	RGD:621558
Mus musculus	VAMP7	MGD	MGI:1096399

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