Ddr2 - discoidin domain receptor tyrosine kinase 2 Gene

Rattus norvegicus

Also known as Tyro10

Gene ID: 685781 | Gene type: protein coding

About Ddr2

Primary_assembly 13: 82,195,463-82,317,363 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 263 orthologues, 54 paralogues and is associated with 32 phenotypes. Biased expression in Uterus (RPKM 164.7), Heart (RPKM 14.2) and 8 other tissues.

Summary

Enables collagen binding activity. Involved in several processes, including negative regulation of cell death; positive regulation of cell population proliferation; and positive regulation of collagen biosynthetic process. Located in apical plasma membrane. Used to study alcoholic liver cirrhosis. Biomarker of alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ddr2 Products(1)

mRNA	Protein	Name
NM_031764.3	NP_113952.2	discoidin domain-containing receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	12220173	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	26674152	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	18664364	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	16087782	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23409069	RGD
involved in negative regulation of hydrogen peroxide-mediated programmed cell death	IMP IMP: Inferred from mutant phenotype	32412792	RGD
involved in negative regulation of kinase activity	IMP IMP: Inferred from mutant phenotype	19762078	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	26674152	RGD
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	32412792	RGD
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	24938620	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	26674152	RGD
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	23409069	RGD
involved in positive regulation of hepatic stellate cell proliferation	IMP IMP: Inferred from mutant phenotype	23409069	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	18664364	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16087782	RGD
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	26674152	RGD
involved in response to muscle stretch	IEP IEP: Inferred from expression pattern	16087782	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15218324	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ddr2 Protein Structure

FA58C

PKc_like

0
200
400
600
800
854 a.a.

Protein Preferred Names

Protein Names

discoidin domain-containing receptor 2

CD167b antigen	discoidin domain receptor family, member 2
neurotrophic tyrosine kinase, receptor-related 3	receptor protein-tyrosine kinase TKT
tyrosine-protein kinase TYRO 10

Recombinant Ddr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75297	DDR2 Protein, Rat (HEK293, His)	B1WC09 (Q24-R399)	≥95%
HY-P75298	DDR2 Protein, Rat (HEK293, hFc)	B1WC09 (Q24-R399)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114169	WRG-28	Inhibitor	99.34%	Unkown
HY-135401	VU6015929	Inhibitor	99.50%	Unkown
HY-114311	FGFR1/DDR2 inhibitor 1	Inhibitor	98.26%	Unkown
HY-114173	DDR1-IN-4	Inhibitor	98.19%	Unkown
HY-156552	DDR1/2 inhibitor-2	Inhibitor	99.73%	Unkown
HY-13979A	DDR1-IN-1 dihydrochloride	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddr2	NCBI	NCBI:4921
Mus musculus	Ddr2	NCBI	NCBI:18214
Macaca mulatta	Ddr2	NCBI	NCBI:720124

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