DDR2 - discoidin domain receptor tyrosine kinase 2 Gene

Homo sapiens

Also known as TKT; WRCN; MIG20a; NTRKR3; TYRO10

Gene ID: 4921 | Gene type: protein coding

About DDR2

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,630,863-162,787,405 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues, 53 paralogues and is associated with 106 phenotypes. Broad expression in fat (RPKM 30.2), adrenal (RPKM 24.5) and 20 other tissues.

Summary

This gene encodes a member of the Discoidin Domain Receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

DDR2 Products(8)

mRNA	Protein	Name
NM_001354983.2	NP_001341912.1	discoidin domain-containing receptor 2 precursor
NM_001014796.3	NP_001014796.1	discoidin domain-containing receptor 2 precursor
NM_001354982.2	NP_001341911.1	discoidin domain-containing receptor 2 precursor
XM_011509587.3	XP_011507889.1	discoidin domain-containing receptor 2 isoform X1
XM_047421554.1	XP_047277510.1	discoidin domain-containing receptor 2 isoform X1
XM_047421565.1	XP_047277521.1	discoidin domain-containing receptor 2 isoform X2
XM_011509588.4	XP_011507890.1	discoidin domain-containing receptor 2 isoform X3
NM_006182.4	NP_006173.2	discoidin domain-containing receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	20004161	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17703188	GOA
enables protein tyrosine kinase collagen receptor activity	IDA IDA: Inferred from direct assay	9659899	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	20004161	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in collagen-activated tyrosine kinase receptor signaling pathway	IDA IDA: Inferred from direct assay	16186108	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	20004161	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16186108	GOA
involved in regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	20564243	GOA
involved in regulation of tissue remodeling	IMP IMP: Inferred from mutant phenotype	30449416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDR2 Protein Structure

F5_F8_type_C

Pkinase_Tyr

0
200
400
600
800
855 a.a.

Protein Preferred Names

Protein Names

discoidin domain-containing receptor 2

CD167 antigen-like family member B	cell migration-inducing protein 20
discoidin domain receptor 2	discoidin domain receptor family, member 2
discoidin domain-containing receptor tyrosine kinase 2	hydroxyaryl-protein kinase
migration-inducing gene 16 protein	neurotrophic tyrosine kinase receptor related 3
receptor protein-tyrosine kinase TKT	tyrosine-protein kinase TYRO10

DDR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDR2	Q16832	COL11A2	Homo sapiens	P13942	NMR	17703188
Intra	DDR2	Q16832	CDC37	Homo sapiens	Q16543	Affinity Chrom	35384245
Intra	DDR2	Q16832	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	DDR2	Q16832	CDC37	Homo sapiens	Q16543	BioID	35384245
Intra	DDR2	Q16832	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	DDR2	Q16832	HSP90AB1	Homo sapiens	P08238	Affinity Chrom	35384245
Intra	DDR2	Q16832	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	DDR2	Q16832	NTRK3	Homo sapiens	Q16288	Anti Tag CoIP	35384245
Intra	DDR2	Q16832	NTRK3	Homo sapiens	Q16288	Affinity Chrom	35384245
Intra	DDR2	Q16832	DDR1	Homo sapiens	Q08345	Affinity Chrom	35384245
Intra	DDR2	Q16832	DDR1	Homo sapiens	Q08345	Anti Tag CoIP	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DDR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76867	DDR2 Protein, Human (sf9, His-GST)	Q16832 (R422-E855)	≥95%
HY-P76868	DDR2 Protein, Human (HEK293, Fc)	Q16832/NP_001014796.1 (K22-R399)	≥95%
HY-P76869	DDR2 Protein, Human (HEK293, His)	Q16832/NP_001014796.1 (K22-R399)	≥95%

Related Diseases

Diseases

Alias

Pectus Excavatum

Funnel Chest

Congenital Pectus Excavatum

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Warburg-Cinotti Syndrome

WRCN

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Adenosquamous Lung Carcinoma

Lung Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lung

Pulmonary Adenoid Cystic Carcinoma

Brachydactyly

Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome	Smed-Sl
Smed-Sl/Ac	Smed Short Limb-Abnormal Calcification Type
Smed Short Limb-Hand Type	Spondylometaepiphyseal Dysplasia Short Limb-Hand Type
Smed, Type Ii	Smed Type 2
Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type	Smed, Short Limb-Hand Type
Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type	Smed, Short Limb-Abnormal Calcification Type
Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification	Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type
SEMD-SL	Smed Type Ii
Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Malignant Squamous Cell Tumor
Squamous Carcinoma	Squamous Cell Epithelioma
Squamous Cell Skin Cancer	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Keloid Formation

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung	Squamous Cell Lung Carcinoma
Epidermoid Cell Carcinoma Of The Lung	Squamous Cell Lung Cancer

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114169	WRG-28	Inhibitor	99.34%	Unkown
HY-135401	VU6015929	Inhibitor	99.50%	Unkown
HY-114311	FGFR1/DDR2 inhibitor 1	Inhibitor	98.26%	Unkown
HY-114173	DDR1-IN-4	Inhibitor	98.19%	Unkown
HY-156552	DDR1/2 inhibitor-2	Inhibitor	99.73%	Unkown
HY-13979A	DDR1-IN-1 dihydrochloride	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDR2	RGD	RGD:619855
Bos taurus	DDR2	VGNC	VGNC:27953
Macaca mulatta	DDR2	VGNC	VGNC:71758
Felis catus	DDR2	VGNC	VGNC:61395
Mus musculus	DDR2	MGD	MGI:1345277
Canis familiaris	DDR2	VGNC	VGNC:39842
Others	DDR2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.