TAL2 - TAL bHLH transcription factor 2 Gene

Homo sapiens

Gene ID: 6887 | Gene type: protein coding

About TAL2

Cytogenetic location: 9q31.2 Genomic coordinates (GRCh38): 9:105,662,457-105,663,124 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues, 4 paralogues and is associated with 30 phenotypes.

Summary

This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

TAL2 Products(1)

mRNA	Protein	Name
NM_005421.3	NP_005412.1	T-cell acute lymphocytic leukemia protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAL2 Protein Structure

HLH

0
100
108 a.a.

Protein Preferred Names

Protein Names

T-cell acute lymphocytic leukemia protein 2

T-cell acute lymphocytic leukemia 2

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Mixed Phenotype Acute Leukemia, B/Myeloid

Doid:0081038

Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia	Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia
T-Cell Childhood Acute Lymphocytic Leukemia	Childhood T Lymphoblastic Leukemia/Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14190	TAL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TAL2	VGNC	VGNC:65946
Macaca mulatta	TAL2	VGNC	VGNC:78095
Mus musculus	TAL2	MGD	MGI:99540
Bos taurus	TAL2	VGNC	VGNC:35589
Canis familiaris	TAL2	VGNC	VGNC:47097
Rattus norvegicus	TAL2	RGD	RGD:1596467

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