1. Gene
  2. MLX - MAX dimerization protein MLX Gene

MLX - MAX dimerization protein MLX Gene

Homo sapiens

Also known as TF4; MAD7; MXD7; TCFL4; bHLHd13

Gene ID: 6945 | Gene type: protein coding

About MLX

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,567,100-42,573,203 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in duodenum (RPKM 29.5), small intestine (RPKM 29.2) and 25 other tissues.

Summary

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MLX Products(3)

mRNA Protein Name
NM_170607.3 NP_733752.1 max-like protein X isoform gamma
NM_198204.2 NP_937847.1 max-like protein X isoform beta
NM_198205.2 NP_937848.1 max-like protein X isoform alpha

MLX Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (130 - 187)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

max-like protein X

BigMax protein

Related Diseases

Diseases Alias
Ovarian Dysgenesis 3

ODG3

Dysgenesis, Ovarian, Type 3

Takayasu Arteritis

Aortic Arch Syndrome

Pulseless Disease

Takayasu'S Arteritis

Idiopathic Aortitis

Young Female Arteritis

Aortic Arch Arteritis

Aortic Arches Defect

Aortic Arch Defects

Takayasu Disease

Aortic Arch Syndromes

Takayasu'S Disease

Ta

Obliterative Aortitis

Aortic Arch Giant-Cell Arteritis

Subclavian-Carotid Obstruction Syndrome

Idiopathic Medial Aortopathy And Arteriopathy

Takayasu Syndrome

Obliterative Brachiocephalic Arteritis Syndrome

Raeder-Harbitz Syndrome

Chronic Subclavian-Carotid Obstruction Syndrome

Giant-Cell Aortitis

Takayasu Aortitis

Nonspecific Aortoarteritis

Sclerosing Aortitis And Arteritis

Martorell 2 Syndrome

Young Female Aortic Arch Arteritis Syndrome

Dental Fluorosis

Mottled Teeth

Intrinsic Enamel Discolouration Of Fluorosis

Mottling Of Enamel

Fluorosis, Dental

Dental Fluorosis, Acquired

Benign Essential Hypertension
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome

Mrxs13

Lindsay-Burn Syndrome

Ppm-X

Ppm-X Syndrome

Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism

Mental Retardation, X-Linked, Syndromic 13

X-Linked Mental Retardation 79

X-Linked Mental Retardation With Spasticity

Intellectual Deficit, X-Linked - Psychosis - Macroorchidism

Intellectual Disability Psychosis Macroorchidism

Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism

Intellectual Disability, X-Linked, Syndromic 13

Ppmx

X-Linked Mental Retardation, Syndromic 13

Olfactory Groove Meningioma

Meningioma Of The Olfactory Groove

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus MLX VGNC VGNC:31508
Mus musculus MLX MGD MGI:108398
Rattus norvegicus MLX RGD RGD:1308590
Canis familiaris MLX VGNC VGNC:43267
Felis catus MLX VGNC VGNC:63528
Macaca mulatta MLX VGNC VGNC:74726