Smyd3 - SET and MYND domain containing 3 Gene

Mus musculus

Also known as Zmynd1; 2410008A19Rik

Gene ID: 69726 | Gene type: protein coding

About Smyd3

Chromosome 1: 178,779,525-179,345,606 reverse strand.GRCm39:CM000994.3

This gene has 7 transcripts (splice variants), 231 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in CNS E18 (RPKM 2.4), cerebellum adult (RPKM 2.2) and 28 other tissues.

Summary

Enables RNA polymerase II complex binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and histone-lysine N-methyltransferase activity. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; nucleosome assembly; and regulation of protein phosphorylation. Located in nucleus. Is expressed in brain; embryo; metanephros; ovary; and thymus. Orthologous to human SMYD3 (SET and MYND domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Smyd3 Products(2)

mRNA	Protein	Name
NM_027188.4	NP_081464.1	histone-lysine N-methyltransferase SMYD3
NM_027188.4	NP_081464.1	histone-lysine N-methyltransferase SMYD3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23752591	MGI
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	23752591	MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23752591	MGI
enables histone H3K36 dimethyltransferase activity	IDA IDA: Inferred from direct assay	16805913	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23752591	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	23752591	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within myotube cell development	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within nucleosome assembly	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23752591	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	23752591	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Smyd3 Protein Structure

SET_SMYD3

zf-MYND

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase SMYD3

SET and MYND domain-containing protein 3	zinc finger MYND domain-containing protein 1
zinc finger, MYND domain containing 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-21972	BCI-121	Inhibitor	99.26%	Unkown
HY-19324	EPZ031686	Inhibitor	99.71%	Unkown
HY-104009A	GSK2807 Trifluoroacetate	Inhibitor	99.36%	Unkown
HY-112080	BAY-6035	Inhibitor	99.82%	Unkown
HY-151379	EM127	Inhibitor	98.37%	Unkown
HY-128352	SMYD3-IN-1	Inhibitor	98.01%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152228	SMYD3-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smyd3	NCBI	NCBI:64754

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