2. Epigenetics
  3. Histone Methyltransferase
  4. BAY-6035

BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM.

For research use only. We do not sell to patients.

BAY-6035 Chemical Structure

BAY-6035 Chemical Structure

CAS No. : 2247890-13-5

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Based on 1 publication(s) in Google Scholar

Other Forms of BAY-6035:

BAY-6035 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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  • Customer Review

Description

BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM[1].

IC50 & Target[1]

SMYD3

88 nM (IC50)

In Vitro

BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC50 of 88 nM and has more than 100-fold selectivity over other histone methyltransferases[1].
BAY-6035 inhibits the methylation of MEKK2 in cells with an IC50 of 70 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-6035 Related Antibodies
Molecular Weight

396.48

Formula

C22H28N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C[C@H](C)N(C(N2CC(C3)C3C2)=O)C4=CC=C(C(NCCC5CC5)=O)C=C4N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (252.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5222 mL 12.6110 mL 25.2220 mL
5 mM 0.5044 mL 2.5222 mL 5.0444 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5222 mL 12.6110 mL 25.2220 mL 63.0549 mL
5 mM 0.5044 mL 2.5222 mL 5.0444 mL 12.6110 mL
10 mM 0.2522 mL 1.2611 mL 2.5222 mL 6.3055 mL
15 mM 0.1681 mL 0.8407 mL 1.6815 mL 4.2037 mL
20 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1527 mL
25 mM 0.1009 mL 0.5044 mL 1.0089 mL 2.5222 mL
30 mM 0.0841 mL 0.4204 mL 0.8407 mL 2.1018 mL
40 mM 0.0631 mL 0.3153 mL 0.6305 mL 1.5764 mL
50 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2611 mL
60 mM 0.0420 mL 0.2102 mL 0.4204 mL 1.0509 mL
80 mM 0.0315 mL 0.1576 mL 0.3153 mL 0.7882 mL
100 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6305 mL
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BAY-6035 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-60352247890-13-5BAY6035BAY 6035Histone MethyltransferaseSMYD3methylationMEKK2Inhibitorinhibitorinhibit

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