TEF - TEF transcription factor, PAR bZIP family member Gene

Homo sapiens

Gene ID: 7008 | Gene type: protein coding

About TEF

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,367,455-41,399,326 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 21.5), ovary (RPKM 19.9) and 24 other tissues.

Summary

This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult Animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with Other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

TEF Products(2)

mRNA	Protein	Name
NM_001145398.3	NP_001138870.1	thyrotroph embryonic factor isoform 2
NM_003216.4	NP_003207.1	thyrotroph embryonic factor isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEF Protein Structure

bZIP_2

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

thyrotroph embryonic factor

TEF, PAR bZIP transcription factor

TEF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TEF	Q10587	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	TEF	Q10587	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	TEF	Q10587	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	TEF	Q10587	MRPL28	Homo sapiens	Q13084	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand

Refractive Amblyopia

Ametropic Amblyopia

Tinea Unguium

Dermatophytosis Of Nail	Onychomycosis Due To Dermatophyte
Cellulitis And Abscess	Cellulitis And Abscess Of Buttock
Cellulitis And Abscess Of Face	Cellulitis And Abscess Of Finger
Cellulitis And Abscess Of Finger And Toe	Cellulitis And Abscess Of Gluteal Region
Cellulitis And Abscess Of Trunk	Cellulitis And Abscess Of Upper Arm And Forearm
Dermatophytic Onychia	Dermatophytic Onychomycosis
Onychomycosis	Ringworm Of Nails
Tinea Of Nail

Thyroid Hormone Resistance, Selective Pituitary

PRTH	Selective Pituitary Thyroid Hormone Resistance
Selective Pituitary Resistance To Thyroid Hormone	Familial Hyperthyroidism Due To Inappropriate Thyrotropin Secretion
Hyperthyroidism, Familial, Due To Inappropriate Thyrotropin Secretion	Pituitary Resistance To Thyroid Hormone

Tinea Cruris

Dermatophytosis Of Groin & Perianal Area	Dermatophytosis Of Groin And Perianal Area
Dhobie Itch	Tinea Of Perianal Region

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14353	TEF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TEF	NCBI	NCBI:21685

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