TGFB1I1 - transforming growth factor beta 1 induced transcript 1 Gene

Homo sapiens

Also known as HIC5; ARA55; HIC-5; TSC-5

Gene ID: 7041 | Gene type: protein coding

About TGFB1I1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,472,152-31,477,960 (from NCBI)

This gene has 17 transcripts (splice variants), 187 orthologues and 2 paralogues. Broad expression in endometrium (RPKM 51.3), prostate (RPKM 29.5) and 20 other tissues.

Summary

This gene encodes a coactivator of the Androgen Receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate Androgen Receptor activity and may have a role to play in the treatment of prostate Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

TGFB1I1 Products(3)

mRNA	Protein	Name
NM_001042454.3	NP_001035919.1	transforming growth factor beta-1-induced transcript 1 protein isoform 1
NM_001164719.1	NP_001158191.1	transforming growth factor beta-1-induced transcript 1 protein isoform 2
NM_015927.5	NP_057011.2	transforming growth factor beta-1-induced transcript 1 protein isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables I-SMAD binding	IPI IPI: Inferred from physical interaction	18762808	GOA
enables Roundabout binding	IPI IPI: Inferred from physical interaction	19855388	GOA
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	10075738	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9756887	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10075738	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	16624805	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10075738	GOA
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	18762808	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	18762808	GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	18762808	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFB1I1 Protein Structure

Paxillin

LIM

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta-1-induced transcript 1 protein

androgen receptor coactivator 55 kDa protein

TGFB1I1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	TGFB1I1	O43294	YPMT1.25Ac	Yersinia pestis	O68743	Y2H Array	21911467
Intra	TGFB1I1	O43294	TRAF4	Homo sapiens	Q9BUZ4	Anti Bait CoIP	16330715
Intra	TGFB1I1	O43294	TRAF4	Homo sapiens	Q9BUZ4	Pull Down	16330715
Intra	TGFB1I1	O43294	TRAF4	Homo sapiens	Q9BUZ4	Confocal	16330715
Intra	TGFB1I1	O43294	TRAF4	Homo sapiens	Q9BUZ4	Y2H	16330715
Intra	TGFB1I1	O43294	PTK2	Homo sapiens	Q05397	Y2H	21900206

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14438	TGFB1I1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TGFB1I1	VGNC	VGNC:47308
Macaca mulatta	TGFB1I1	VGNC	VGNC:78333
Rattus norvegicus	TGFB1I1	RGD	RGD:620173
Felis catus	TGFB1I1	VGNC	VGNC:66132
Bos taurus	TGFB1I1	VGNC	VGNC:35801
Mus musculus	TGFB1I1	MGD	MGI:102784

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