PTK2 - protein tyrosine kinase 2 Gene

Homo sapiens

Also known as FAK; FADK; FAK1; FRNK; FADK 1; PPP1R71; p125FAK; pp125FAK

Gene ID: 5747 | Gene type: protein coding

About PTK2

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:140,657,900-141,002,079 (from NCBI)

This gene has 58 transcripts (splice variants), 230 orthologues and 32 paralogues. Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues.

Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of Protein Tyrosine Kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural Peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

PTK2 Products(181)

mRNA	Protein	Name
XM_024447208.2	XP_024302976.1	focal adhesion kinase 1 isoform X28
NM_001387591.1	NP_001374520.1	focal adhesion kinase 1 isoform 54
NM_001387649.1	NP_001374578.1	focal adhesion kinase 1 isoform 63
NM_001352715.2	NP_001339644.1	focal adhesion kinase 1 isoform 14
NM_001352707.2	NP_001339636.1	focal adhesion kinase 1 isoform 10
NM_001387657.1	NP_001374586.1	focal adhesion kinase 1 isoform 1
NR_148038.2
NM_001387661.1	NP_001374590.1	focal adhesion kinase 1 isoform 65
NM_001387650.1	NP_001374579.1	focal adhesion kinase 1 isoform 65
NM_001316342.2	NP_001303271.1	focal adhesion kinase 1 isoform 4
NM_001387603.1	NP_001374532.1	focal adhesion kinase 1 isoform 55
NM_001387644.1	NP_001374573.1	focal adhesion kinase 1 isoform 62
XM_047422027.1	XP_047277983.1	focal adhesion kinase 1 isoform X10
NM_001352716.2	NP_001339645.1	focal adhesion kinase 1 isoform 15
XM_047422023.1	XP_047277979.1	focal adhesion kinase 1 isoform X6
NM_001387592.1	NP_001374521.1	focal adhesion kinase 1 isoform 71
NM_001352739.2	NP_001339668.1	focal adhesion kinase 1 isoform 33
NM_001352748.2	NP_001339677.1	focal adhesion kinase 1 isoform 41
XM_047422036.1	XP_047277992.1	focal adhesion kinase 1 isoform X21
NM_005607.5	NP_005598.3	focal adhesion kinase 1 isoform 2
XM_047422054.1	XP_047278010.1	focal adhesion kinase 1 isoform X38
NM_001352700.2	NP_001339629.1	focal adhesion kinase 1 isoform 7
NM_001352745.2	NP_001339674.1	focal adhesion kinase 1 isoform 38
NM_001352736.2	NP_001339665.1	focal adhesion kinase 1 isoform 30
NM_001387620.1	NP_001374549.1	focal adhesion kinase 1 isoform 4
XM_047422025.1	XP_047277981.1	focal adhesion kinase 1 isoform X8
NM_001352701.2	NP_001339630.1	focal adhesion kinase 1 isoform 7
NM_001352724.2	NP_001339653.1	focal adhesion kinase 1 isoform 19
NM_001387643.1	NP_001374572.1	focal adhesion kinase 1 isoform 65
XM_047422049.1	XP_047278005.1	focal adhesion kinase 1 isoform X24
NR_148036.2
NM_001387623.1	NP_001374552.1	focal adhesion kinase 1 isoform 56
NM_001387617.1	NP_001374546.1	focal adhesion kinase 1 isoform 71
NM_001352732.2	NP_001339661.1	focal adhesion kinase 1 isoform 27
XM_047422046.1	XP_047278002.1	focal adhesion kinase 1 isoform X33
NM_001387614.1	NP_001374543.1	focal adhesion kinase 1 isoform 59
NR_170673.1
XM_047422030.1	XP_047277986.1	focal adhesion kinase 1 isoform X13
NM_001352698.2	NP_001339627.1	focal adhesion kinase 1 isoform 6
NM_001352740.2	NP_001339669.1	focal adhesion kinase 1 isoform 34
NM_001352694.2	NP_001339623.1	focal adhesion kinase 1 isoform 1
NM_001387619.1	NP_001374548.1	focal adhesion kinase 1 isoform 23
NM_001387587.1	NP_001374516.1	focal adhesion kinase 1 isoform 1
XM_047422018.1	XP_047277974.1	focal adhesion kinase 1 isoform X3
NM_001387618.1	NP_001374547.1	focal adhesion kinase 1 isoform 56
NM_001352752.2	NP_001339681.1	focal adhesion kinase 1 isoform 45
NM_001352705.2	NP_001339634.1	focal adhesion kinase 1 isoform 9
NM_001352747.2	NP_001339676.1	focal adhesion kinase 1 isoform 40
NM_001387627.1	NP_001374556.1	focal adhesion kinase 1 isoform 60
XM_047422026.1	XP_047277982.1	focal adhesion kinase 1 isoform X9
NM_001387633.1	NP_001374562.1	focal adhesion kinase 1 isoform 68
NM_001352723.2	NP_001339652.1	focal adhesion kinase 1 isoform 18
NM_001387647.1	NP_001374576.1	focal adhesion kinase 1 isoform 1
NM_001352749.2	NP_001339678.1	focal adhesion kinase 1 isoform 42
XM_047422038.1	XP_047277994.1	focal adhesion kinase 1 isoform X23
NM_001352731.2	NP_001339660.1	focal adhesion kinase 1 isoform 26
XM_047422053.1	XP_047278009.1	focal adhesion kinase 1 isoform X24
NM_001387655.1	NP_001374584.1	focal adhesion kinase 1 isoform 1
NM_001387660.1	NP_001374589.1	focal adhesion kinase 1 isoform 65
NM_001352733.2	NP_001339662.1	focal adhesion kinase 1 isoform 28
NM_001352711.2	NP_001339640.1	focal adhesion kinase 1 isoform 11
XM_047422050.1	XP_047278006.1	focal adhesion kinase 1 isoform X36
NM_001387625.1	NP_001374554.1	focal adhesion kinase 1 isoform 20
NM_001387632.1	NP_001374561.1	focal adhesion kinase 1 isoform 59
NM_001352703.2	NP_001339632.1	focal adhesion kinase 1 isoform 7
NM_001352710.2	NP_001339639.1	focal adhesion kinase 1 isoform 10
XM_047422032.1	XP_047277988.1	focal adhesion kinase 1 isoform X15
NM_001387612.1	NP_001374541.1	focal adhesion kinase 1 isoform 56
NM_001387651.1	NP_001374580.1	focal adhesion kinase 1 isoform 69
NM_001352725.2	NP_001339654.1	focal adhesion kinase 1 isoform 20
XM_047422020.1	XP_047277976.1	focal adhesion kinase 1 isoform X4
NM_001387613.1	NP_001374542.1	focal adhesion kinase 1 isoform 35
NM_001387662.1	NP_001374591.1	focal adhesion kinase 1 isoform 61
NM_001387630.1	NP_001374559.1	focal adhesion kinase 1 isoform 52
NM_001352743.2	NP_001339672.1	focal adhesion kinase 1 isoform 47
NM_001352744.2	NP_001339673.1	focal adhesion kinase 1 isoform 37
NM_001352728.2	NP_001339657.1	focal adhesion kinase 1 isoform 23
NM_001387610.1	NP_001374539.1	focal adhesion kinase 1 isoform 52
NM_001352695.2	NP_001339624.1	focal adhesion kinase 1 isoform 48
NM_001387658.1	NP_001374587.1	focal adhesion kinase 1 isoform 1
XM_047422047.1	XP_047278003.1	focal adhesion kinase 1 isoform X34
NM_001352697.2	NP_001339626.1	focal adhesion kinase 1 isoform 5
NM_001352737.2	NP_001339666.1	focal adhesion kinase 1 isoform 31
NM_001352719.2	NP_001339648.1	focal adhesion kinase 1 isoform 17
NM_001352706.2	NP_001339635.1	focal adhesion kinase 1 isoform 10
NM_001387636.1	NP_001374565.1	focal adhesion kinase 1 isoform 1
NM_001352714.2	NP_001339643.1	focal adhesion kinase 1 isoform 13
XM_047422037.1	XP_047277993.1	focal adhesion kinase 1 isoform X22
XM_047422019.1	XP_047277975.1	focal adhesion kinase 1 isoform X4
NM_001352712.2	NP_001339641.1	focal adhesion kinase 1 isoform 12
NM_001387639.1	NP_001374568.1	focal adhesion kinase 1 isoform 10
NM_001352742.2	NP_001339671.1	focal adhesion kinase 1 isoform 36
NM_001387615.1	NP_001374544.1	focal adhesion kinase 1 isoform 21
NM_001387624.1	NP_001374553.1	focal adhesion kinase 1 isoform 15
NR_170671.1
NM_001387648.1	NP_001374577.1	focal adhesion kinase 1 isoform 65
XM_047422039.1	XP_047277995.1	focal adhesion kinase 1 isoform X24
NM_001352734.2	NP_001339663.1	focal adhesion kinase 1 isoform 29
XM_024447203.2	XP_024302971.1	focal adhesion kinase 1 isoform X17
NM_001352750.2	NP_001339679.1	focal adhesion kinase 1 isoform 43
XM_047422044.1	XP_047278000.1	focal adhesion kinase 1 isoform X31
NM_001387642.1	NP_001374571.1	focal adhesion kinase 1 isoform 1
NM_001387656.1	NP_001374585.1	focal adhesion kinase 1 isoform 20
NM_001352696.2	NP_001339625.1	focal adhesion kinase 1 isoform 4
NM_001352751.2	NP_001339680.1	focal adhesion kinase 1 isoform 44
NM_001352721.2	NP_001339650.1	focal adhesion kinase 1 isoform 18
NM_001387654.1	NP_001374583.1	focal adhesion kinase 1 isoform 56
NM_001387638.1	NP_001374567.1	focal adhesion kinase 1 isoform 17
NM_001387645.1	NP_001374574.1	focal adhesion kinase 1 isoform 1
NM_001352717.2	NP_001339646.1	focal adhesion kinase 1 isoform 16
XM_047422029.1	XP_047277985.1	focal adhesion kinase 1 isoform X12
XM_047422022.1	XP_047277978.1	focal adhesion kinase 1 isoform X5
NM_001352713.2	NP_001339642.1	focal adhesion kinase 1 isoform 13
NM_001387584.1	NP_001374513.1	focal adhesion kinase 1 isoform 56
NM_001352704.2	NP_001339633.1	focal adhesion kinase 1 isoform 8
NM_001387611.1	NP_001374540.1	focal adhesion kinase 1 isoform 57
NM_001387652.1	NP_001374581.1	focal adhesion kinase 1 isoform 56
XM_047422028.1	XP_047277984.1	focal adhesion kinase 1 isoform X11
NM_001387628.1	NP_001374557.1	focal adhesion kinase 1 isoform 1
NM_001199649.2	NP_001186578.1	focal adhesion kinase 1 isoform 3
XM_024447209.2	XP_024302977.1	focal adhesion kinase 1 isoform X30
NM_001352709.2	NP_001339638.1	focal adhesion kinase 1 isoform 10
XM_024447207.2	XP_024302975.1	focal adhesion kinase 1 isoform X27
NM_001387646.1	NP_001374575.1	focal adhesion kinase 1 isoform 65
NM_001387607.1	NP_001374536.1	focal adhesion kinase 1 isoform 58
NM_001387631.1	NP_001374560.1	focal adhesion kinase 1 isoform 15
NM_001352741.2	NP_001339670.1	focal adhesion kinase 1 isoform 35
NM_001387653.1	NP_001374582.1	focal adhesion kinase 1 isoform 23
XM_047422035.1	XP_047277991.1	focal adhesion kinase 1 isoform X20
NM_001387637.1	NP_001374566.1	focal adhesion kinase 1 isoform 1
XM_047422043.1	XP_047277999.1	focal adhesion kinase 1 isoform X29
NM_001387588.1	NP_001374517.1	focal adhesion kinase 1 isoform 69
NM_001387608.1	NP_001374537.1	focal adhesion kinase 1 isoform 56
XM_047422041.1	XP_047277997.1	focal adhesion kinase 1 isoform X26
XM_047422031.1	XP_047277987.1	focal adhesion kinase 1 isoform X14
XM_047422017.1	XP_047277973.1	focal adhesion kinase 1 isoform X2
NM_001352720.2	NP_001339649.1	focal adhesion kinase 1 isoform 17
NM_001387586.1	NP_001374515.1	focal adhesion kinase 1 isoform 1
NM_001352718.2	NP_001339647.1	focal adhesion kinase 1 isoform 17
NM_001387621.1	NP_001374550.1	focal adhesion kinase 1 isoform 71
NM_001387622.1	NP_001374551.1	focal adhesion kinase 1 isoform 16
NM_001387606.1	NP_001374535.1	focal adhesion kinase 1 isoform 33
NM_001352746.2	NP_001339675.1	focal adhesion kinase 1 isoform 39
XM_047422040.1	XP_047277996.1	focal adhesion kinase 1 isoform X25
NM_001387604.1	NP_001374533.1	focal adhesion kinase 1 isoform 49
NM_001387659.1	NP_001374588.1	focal adhesion kinase 1 isoform 17
XM_047422034.1	XP_047277990.1	focal adhesion kinase 1 isoform X19
NM_001352729.2	NP_001339658.1	focal adhesion kinase 1 isoform 24
NR_170670.1
NM_001352730.2	NP_001339659.1	focal adhesion kinase 1 isoform 25
NM_001387635.1	NP_001374564.1	focal adhesion kinase 1 isoform 53
XM_047422052.1	XP_047278008.1	focal adhesion kinase 1 isoform X37
XM_047422048.1	XP_047278004.1	focal adhesion kinase 1 isoform X35
NM_153831.4	NP_722560.1	focal adhesion kinase 1 isoform 1
NM_001352702.2	NP_001339631.1	focal adhesion kinase 1 isoform 7
NM_001352699.2	NP_001339628.1	focal adhesion kinase 1 isoform 7
NM_001387609.1	NP_001374538.1	focal adhesion kinase 1 isoform 35
XM_047422024.1	XP_047277980.1	focal adhesion kinase 1 isoform X7
XM_047422033.1	XP_047277989.1	focal adhesion kinase 1 isoform X18
NM_001387640.1	NP_001374569.1	focal adhesion kinase 1 isoform 64
NM_001387589.1	NP_001374518.1	focal adhesion kinase 1 isoform 70
NM_001352726.2	NP_001339655.1	focal adhesion kinase 1 isoform 21
NM_001352722.2	NP_001339651.1	focal adhesion kinase 1 isoform 18
NM_001352735.2	NP_001339664.1	focal adhesion kinase 1 isoform 46
NR_148037.2
NR_170672.1
XM_047422045.1	XP_047278001.1	focal adhesion kinase 1 isoform X32
NM_001352727.2	NP_001339656.1	focal adhesion kinase 1 isoform 22
NM_001387641.1	NP_001374570.1	focal adhesion kinase 1 isoform 72
NM_001387585.1	NP_001374514.1	focal adhesion kinase 1 isoform 59
NM_001387629.1	NP_001374558.1	focal adhesion kinase 1 isoform 50
NM_001387634.1	NP_001374563.1	focal adhesion kinase 1 isoform 14
XM_047422021.1	XP_047277977.1	focal adhesion kinase 1 isoform X4
NM_001387605.1	NP_001374534.1	focal adhesion kinase 1 isoform 56
NM_001387616.1	NP_001374545.1	focal adhesion kinase 1 isoform 71
NM_001352708.2	NP_001339637.1	focal adhesion kinase 1 isoform 10
XM_024447202.2	XP_024302970.1	focal adhesion kinase 1 isoform X16
NM_001352738.2	NP_001339667.1	focal adhesion kinase 1 isoform 32
XM_047422016.1	XP_047277972.1	focal adhesion kinase 1 isoform X1
NR_148039.2
NM_001387590.1	NP_001374519.1	focal adhesion kinase 1 isoform 53

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables JUN kinase binding	IDA IDA: Inferred from direct assay	10925297	GOA
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	15077193	GOA
enables actin binding	IDA IDA: Inferred from direct assay	16803572	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	26763945	GOA
enables molecular function activator activity	EXP EXP: Inferred from Experiment	12467573	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10655584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7561682	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19118217	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	28759036	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	12235133	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	9360983	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20305651	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	10655584	GOA
involved in growth hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	10925297	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	24036928	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11331870	GOA
involved in negative regulation of anoikis	IMP IMP: Inferred from mutant phenotype	22402981	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15166238	GOA
involved in negative regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	21703394	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10655584	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11331870	GOA
involved in positive regulation of epithelial cell migration	IGI IGI: Inferred from genetic interaction	26944318	GOA
involved in positive regulation of epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	26944318	GOA
involved in positive regulation of fibroblast migration	IDA IDA: Inferred from direct assay	26763945	GOA
acts upstream of positive regulation of macrophage chemotaxis	IGI IGI: Inferred from genetic interaction	26754294	GOA
acts upstream of positive regulation of macrophage proliferation	IGI IGI: Inferred from genetic interaction	26754294	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	26944318	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	15166238	GOA
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	11331870	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15166238	GOA
involved in positive regulation of wound healing	IDA IDA: Inferred from direct assay	26763945	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10655584	GOA
involved in regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	10655584	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18206965	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	10655584	GOA
involved in regulation of epithelial cell migration	IGI IGI: Inferred from genetic interaction	19913511	GOA
involved in regulation of focal adhesion assembly	IGI IGI: Inferred from genetic interaction	19913511	GOA
involved in regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	16927379	GOA
involved in regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	19913511	GOA
involved in regulation of substrate adhesion-dependent cell spreading	IGI IGI: Inferred from genetic interaction	19913511	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	24036928	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	31630787	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15855171	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	10655584	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15855171	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	24036928	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTK2 Protein Structure

FERM_M

Pkinase_Tyr

Focal_AT

0
200
400
600
800
1000
1052 a.a.

Protein Preferred Names

Protein Names

focal adhesion kinase 1

FAK-related non-kinase polypeptide	PTK2 protein tyrosine kinase 2
focal adhesion kinase-related nonkinase	protein phosphatase 1 regulatory subunit 71

PTK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTK2	Q05397	TGFB1I1	Homo sapiens	O43294	Anti Bait CoIP	9756887
Intra	PTK2	Q05397	TGFB1I1	Homo sapiens	O43294	Pull Down	32707033
Intra	PTK2	Q05397	PTRH2	Homo sapiens	Q9Y3E5	Anti Bait CoIP	21383007
Intra	PTK2	Q05397	STAT1	Homo sapiens	P42224	Anti Bait CoIP	20576130
Intra	PTK2	Q05397	TNS3	Homo sapiens	Q68CZ2	Far-WB	19732724
Intra	PTK2	Q05397	EGFR	Homo sapiens	P00533	Anti Bait CoIP	20473329
Cross	PTK2	Q05397	Src	Mus musculus	P05480	NMR	18560762
Cross	PTK2	Q05397	Src	Mus musculus	P05480	ITC	21266176
Intra	PTK2	Q05397	TP53	Homo sapiens	P04637	Anti Bait CoIP	15855171
Intra	PTK2	Q05397	TP53	Homo sapiens	P04637	Confocal	15855171
Intra	PTK2	Q05397	TP53	Homo sapiens	P04637	Pull Down	15855171
Intra	PTK2	Q05397	PTAFR	Homo sapiens	P25105	Anti Bait CoIP	20576130
Intra	PTK2	Q05397	GRB2	Homo sapiens	P62993	Y2H	21900206
Intra	PTK2	Q05397	GRB2	Homo sapiens	P62993	Anti Bait CoIP	20473329
Intra	PTK2	Q05397	FYN	Homo sapiens	P06241	Pull Down	32707033
Intra	PTK2	Q05397	SRPK1	Homo sapiens	Q96SB4	Pull Down	32707033
Intra	PTK2	Q05397	SRC	Homo sapiens	P12931	Anti Bait CoIP	16291744
Intra	PTK2	Q05397	SRC	Homo sapiens	P12931	Anti Bait CoIP	17525734
Intra	PTK2	Q05397	SRC	Homo sapiens	P12931	PLA	25241761
Intra	PTK2	Q05397	SRC	Homo sapiens	P12931	PLA	23065768
Intra	PTK2	Q05397	SRC	Homo sapiens	P12931	Anti Tag CoIP	16966330
Intra	PTK2	Q05397	SRC	Homo sapiens	P12931	Y2H Array	25814554
Intra	PTK2	Q05397	SRC	Homo sapiens	P12931	Lumier	32814053
Cross	PTK2	Q05397	Tgfb1i1	Mus musculus	Q62219	Pull Down	9756887
Cross	PTK2	Q05397	Tgfb1i1	Mus musculus	Q62219	Anti Tag CoIP	9756887
Intra	PTK2	Q05397	BCAR1	Homo sapiens	P56945	CoIP	21034468
Intra	PTK2	Q05397	BCAR1	Homo sapiens	P56945	Filter Binding	9285683
Intra	PTK2	Q05397	EPHA2	Homo sapiens	P29317	IF	10655584
Intra	PTK2	Q05397	EPHA2	Homo sapiens	P29317	Anti Bait CoIP	10655584
Intra	PTK2	Q05397	PXN	Homo sapiens	P49023	Anti Tag CoIP	9756887
Intra	PTK2	Q05397	PXN	Homo sapiens	P49023	Far-WB	7561682
Intra	PTK2	Q05397	PXN	Homo sapiens	P49023	Pull Down	32707033
Intra	PTK2	Q05397	PXN	Homo sapiens	P49023	Pull Down	7561682
Intra	PTK2	Q05397	PXN	Homo sapiens	P49023	Anti Bait CoIP	21741599
Intra	PTK2	Q05397	PTPN6	Homo sapiens	P29350-3	Lumier	25814554
Intra	PTK2	Q05397	PTPN6	Homo sapiens	P29350-3	Validated Y2H	25814554
Intra	PTK2	Q05397	PIK3R3	Homo sapiens	Q92569	Anti Bait CoIP	22402981
Intra	PTK2	Q05397	ITGB4	Homo sapiens	P16144	Anti Bait CoIP	27178753
Intra	PTK2	Q05397	ITGB4	Homo sapiens	P16144	Anti Tag CoIP	27178753
Intra	PTK2	Q05397	GRB7	Homo sapiens	Q14451	Validated Y2H	25814554
Cross	PTK2	Q05397	q824h6_chlcv	Chlamydophila caviae	Q824H6	Y2H	25193659

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia	Thrombasthenia Of Glanzmann And Naegeli
Bdplt2	Platelet Glycoprotein Iib-Iiia Deficiency
Glanzmann'S Thrombasthenia	Deficiency Of Platelet Fibrinogen Receptor
GT1	Gt
Platelet Fibrinogen Receptor Deficiency	Glycoprotein Complex Iib-Iiia Deficiency
Deficiency Of Glycoprotein Complex Iib-Iiia	Glycoprotein Iib/Iiia Defect
Glanzmann Thrombasthenia, Type A	Thrombasthenia
Bleeding Disorder, Platelet-Type, 2	Gp Iib-Iiia Complex Deficiency
Deficiency Of Gp Iib-Iiia Complex	Platelet-Type Bleeding Disorder 2
Thrombocytasthenia	Deficiency Of Gp 2b 3a Complex
Diacyclothrombopathia 2b 3a	Glanzmann Thrombasthenia Type A
Platelet Fibrinogen Receptor, Deficiency Of	Platelet Glycoprotein 2b 3a Deficiency
Glanzmann Disease	Glanzmann-Naegeli Disorder
Hereditary Hemorrhagic Thrombasthenia	Hereditary Thrombasthenia
Bleeding Disorder Platelet-Type 2

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Nephrotic Syndrome, Type 10

NPHS10	Nephrotic Syndrome Type 10
Idiopathic Steroid-Sensitive Nephrotic Syndrome	Nephrotic Syndrome 10

Malignant Pleural Mesothelioma

Malignant Mesothelioma Of Pleura

Pleural Malignant Mesothelioma

Thrombasthenia

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Larynx
Squamous Cell Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Head And Neck

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Head And Neck Cancer
Squamous Cell Carcinoma Of Lip	Squamous Cell Carcinoma, Head And Neck, Somatic
Carcinoma Of The Head And Neck	Squamous Cell Carcinomas Of Head And Neck
Scchn	Squamous Cell Carcinoma Of The Hypopharynx
Squamous Cell Carcinoma Of The Oropharynx	Squamous Cell Carcinoma Of Salivary Glands
Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses	Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses
Squamous Cell Carcinoma Of The Oral Cavity	Squamous Cell Carcinoma Of The Lip
Carcinoma, Squamous Cell Of Head And Neck	Lip Squamous Cell Carcinoma
Cancer, Head/Neck	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To	Extrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma	Chlc
Chlc, Susceptibility To	Cc
Cholangiocarcinoma Of Biliary Tract	Cholangiocellular Carcinoma
Distal Cholangiocarcinoma	Perihilar Cholangiocarcinoma
Bile Duct Cancer	Cca
Adult Primary Cholangiocellular Carcinoma	Bile Duct Carcinoma

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Glioma

Rhabdomyosarcoma

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Ewings Sarcoma	Ewing'S Sarcoma
Peripheral Neuroepithelioma	Primitive Neuroectodermal Tumor
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Extraosseous Ewing Tumor	Askin Tumor
Ewing'S Family Localized Tumor	Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing Sarcoma	Localized Ewing'S Sarcoma
Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing'S Tumor
Pnet Of Thoracopulmonary Region	Ewing Family Of Tumors
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111546	BI-3663	Inhibitor	99.90%	Unkown
HY-123919	TL13-112	Inhibitor	98.15%	Unkown
HY-124625	BI-4464	Inhibitor	98.64%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-122582	TL13-12	Inhibitor	98.06%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-130422	Tos-PEG4-t-butyl ester		/	Unkown
HY-130521	Pomalidomide-amido-PEG3-C2-NH2		99.55%	Unkown
HY-RS11400	Ptk2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-136194	TL13-22	Inhibitor	99.71%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-RS11399	PTK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11401	Ptk2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11402	PTK2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTK2	MGD	MGI:95481
Rattus norvegicus	PTK2	RGD	RGD:3443
Macaca mulatta	PTK2	VGNC	VGNC:84105
Bos taurus	PTK2	VGNC	VGNC:33518
Felis catus	PTK2	VGNC	VGNC:82498
Canis familiaris	PTK2	VGNC	VGNC:45158
Others	PTK2	NCBI