TIAL1 - TIA1 cytotoxic granule associated RNA binding protein like 1 Gene

Homo sapiens

Also known as TCBP; TIAR

Gene ID: 7073 | Gene type: protein coding

About TIAL1

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,573,465-119,596,964 (from NCBI)

This gene has 13 transcripts (splice variants), 116 orthologues and 36 paralogues. Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and Apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

TIAL1 Products(8)

mRNA	Protein	Name
NM_001033925.2	NP_001029097.1	nucleolysin TIAR isoform 2
NM_001323964.2	NP_001310893.1	nucleolysin TIAR isoform 3
NM_001323965.2	NP_001310894.1	nucleolysin TIAR isoform 3
NM_001323967.2	NP_001310896.1	nucleolysin TIAR isoform 3
NM_001323968.2	NP_001310897.1	nucleolysin TIAR isoform 4
NM_001323969.2	NP_001310898.1	nucleolysin TIAR isoform 5
NM_001323970.2	NP_001310899.1	nucleolysin TIAR isoform 6
NM_003252.4	NP_003243.1	nucleolysin TIAR isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	33203680	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein-RNA adaptor activity	IDA IDA: Inferred from direct assay	33203680	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	33203680	GOA
involved in positive regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	33203680	GOA
involved in positive regulation of miRNA-mediated gene silencing	IGI IGI: Inferred from genetic interaction	33203680	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIAL1 Protein Structure

RRM_1

0
100
200
300
375 a.a.

Protein Preferred Names

Protein Names

nucleolysin TIAR

T-cluster binding protein

TIAL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TIAL1	Q01085	MOV10	Homo sapiens	Q9HCE1	Anti Bait CoIP	34517762

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ulcerative Blepharitis

Salpingitis Isthmica Nodosa

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14514	TIAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14520	TIE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-15973	BSF-466895	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TIAL1	VGNC	VGNC:35859
Rattus norvegicus	TIAL1	RGD	RGD:1595845
Macaca mulatta	TIAL1	VGNC	VGNC:78354
Mus musculus	TIAL1	MGD	MGI:107913
Canis familiaris	TIAL1	VGNC	VGNC:47364
Felis catus	TIAL1	VGNC	VGNC:66182

Name
Email *

	Sorry, but the email address you supplied was invalid.