2. Gene
  3. MOV10 - Mov10 RISC complex RNA helicase Gene

MOV10 - Mov10 RISC complex RNA helicase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as gb110; fSAP113

Gene ID: 4343 | Gene type: protein coding

About MOV10

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,674,439-112,700,739 (from NCBI)

This gene has 26 transcripts (splice variants), 295 orthologues and 10 paralogues. Ubiquitous expression in placenta (RPKM 19.5), small intestine (RPKM 18.6) and 25 other tissues.

Summary

Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus; negative regulation of transposition, RNA-mediated; and posttranscriptional regulation of gene expression. Located in P-body and cytosol. Implicated in hypertension. [provided by Alliance of Genome Resources, Apr 2022]

MOV10 Products(7)

mRNA Protein Name
NM_001130079.3 NP_001123551.1 helicase MOV-10 isoform 1
NM_001286072.2 NP_001273001.1 helicase MOV-10 isoform 2
NM_001321324.2 NP_001308253.1 helicase MOV-10 isoform 1
NM_001369507.1 NP_001356436.1 helicase MOV-10 isoform 1
NM_001389562.1 NP_001376491.1 helicase MOV-10 isoform 2
NM_001389563.1 NP_001376492.1 helicase MOV-10 isoform 2
NM_020963.5 NP_066014.1 helicase MOV-10 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 5'-3' RNA helicase activity IDA
IDA: Inferred from direct assay
24726324 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
23093941 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16289642 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
24726324 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
27974568 GOA
involved in miRNA-mediated gene silencing by mRNA destabilization IDA
IDA: Inferred from direct assay
16289642 GOA
involved in miRNA-mediated post-transcriptional gene silencing IMP
IMP: Inferred from mutant phenotype
17507929 GOA
involved in positive regulation of mRNA catabolic process IDA
IDA: Inferred from direct assay
24726324 GOA
involved in retrotransposon silencing IDA
IDA: Inferred from direct assay
23093941 GOA
involved in retrotransposon silencing by mRNA destabilization IDA
IDA: Inferred from direct assay
30122351 GOA
Cellular Component GO Annotation Evidence Reference Source
located in P-body IDA
IDA: Inferred from direct assay
16289642 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
30122351 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOV10 Protein Structure

AAA_11

AAA_11: AAA domain (499 - 596)

AAA_11

AAA_11: AAA domain (610 - 690)

AAA_12

AAA_12: AAA domain (700 - 922)

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  • 1003 a.a.
Protein Preferred Names Protein Names

helicase MOV-10

Mov10, Moloney leukemia virus 10, homolog

MOV10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MOV10 Q9HCE1 IGF2BP1 Homo sapiens Q9NZI8
Anti Tag CoIP
20543829
Cross
MOV10 Q9HCE1 Cbx7 Mus musculus Q8VDS3
Pull Down
20543829
Cross
MOV10 Q9HCE1 Cbx7 Mus musculus Q8VDS3
Anti Tag CoIP
20543829
Cross
MOV10 Q9HCE1 shdag_hdvd3 Hepatitis delta virus P0C6L3
Anti Tag CoIP
18552826
Intra
MOV10 Q9HCE1 PCGF2 Homo sapiens P35227
Anti Bait CoIP
20543829
Intra
MOV10 Q9HCE1 PCGF2 Homo sapiens P35227
Anti Tag CoIP
20543829
Intra
MOV10 Q9HCE1 BMI1 Homo sapiens P35226
Anti Bait CoIP
20543829
Intra
MOV10 Q9HCE1 BMI1 Homo sapiens P35226
Anti Tag CoIP
20543829
Cross
MOV10 Q9HCE1 N SARS-CoV-2 P0DTC9
Confocal
35107372
Cross
MOV10 Q9HCE1 N SARS-CoV-2 P0DTC9
Anti Bait CoIP
35107372
Intra
MOV10 Q9HCE1 TIAL1 Homo sapiens Q01085
Anti Bait CoIP
34517762
Intra
MOV10 Q9HCE1 CBX7 Homo sapiens O95931
Anti Bait CoIP
20543829
Intra
MOV10 Q9HCE1 CBX7 Homo sapiens O95931
Anti Tag CoIP
20543829
Intra
MOV10 Q9HCE1 CBX6 Homo sapiens O95503
Anti Tag CoIP
20543829
Intra
MOV10 Q9HCE1 EIF2AK2 Homo sapiens P19525
Anti Tag CoIP
21903422
Intra
MOV10 Q9HCE1 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
20543829
Intra
MOV10 Q9HCE1 CBX8 Homo sapiens Q9HC52
Anti Bait CoIP
20543829
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08603 MOV10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08604 MOV10L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MOV10 VGNC VGNC:106410
Felis catus MOV10 VGNC VGNC:68302
Mus musculus MOV10 MGD MGI:97054
Canis familiaris MOV10 VGNC VGNC:43327
Bos taurus MOV10 VGNC VGNC:31566
Rattus norvegicus MOV10 RGD RGD:1598327