2. Gene
  3. TNFAIP6 - TNF alpha induced protein 6 Gene

TNFAIP6 - TNF alpha induced protein 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TSG6; TSG-6

Gene ID: 7130 | Gene type: protein coding

About TNFAIP6

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:151,357,592-151,381,340 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 2 paralogues. Biased expression in appendix (RPKM 17.8), gall bladder (RPKM 12.0) and 11 other tissues.

Summary

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine Protease inhibitory activity of I alpha I, which is important in the Protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]

TNFAIP6 Products(2)

mRNA Protein Name
NM_007115.4 NP_009046.2 tumor necrosis factor-inducible gene 6 protein precursor
NM_007115.4 NP_009046.2 tumor necrosis factor-inducible gene 6 protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
26468290 GOA
enables carboxylesterase activity IDA
IDA: Inferred from direct assay
16873769 GOA
enables fibronectin binding IDA
IDA: Inferred from direct assay
18042364 GOA
enables hyaluronic acid binding IDA
IDA: Inferred from direct assay
26468290 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16771708 GOA
Biological Process GO Annotation Evidence Reference Source
involved in fibronectin fibril organization IDA
IDA: Inferred from direct assay
18042364 GOA
involved in hyaluronan metabolic process IDA
IDA: Inferred from direct assay
20463016 GOA
involved in negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
16771708 GOA
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
21569482 GOA
involved in negative regulation of neutrophil chemotaxis IDA
IDA: Inferred from direct assay
24501198 GOA
involved in negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
16771708 GOA
involved in negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
18586671 GOA
involved in positive regulation of receptor clustering IDA
IDA: Inferred from direct assay
26823460 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular region IDA
IDA: Inferred from direct assay
1730767 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP6 Protein Structure

Xlink

Xlink: Extracellular link domain (36 - 128)

CUB

CUB: CUB domain (135 - 244)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor-inducible gene 6 protein

TNF-stimulated gene 6 protein

Related Diseases

Diseases Alias
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Osteoarthritis

Osteoarthrosis

Degenerative Joint Disease

Hypertrophic Arthritis

Arthropathy

Degenerative Polyarthritis

Degenerative Arthritis

Osteoarthrosis And Allied Disorder

Arthritis, Degenerative

Oa

Osteoarthritis Deformans

Osteoarthrosis Deformans

Kashin-Beck Disease
Mucopolysaccharidosis, Type Ix

Mucopolysaccharidosis Type Ix

Hyaluronidase Deficiency

MPS9

Mps Ix

Mucopolysaccharidosis Ix

Mpsix

Mucopolysaccharidosis Type 9

Mucopolysaccharidosis 9
Anal Fistula

Anorectal Fistula

Rectal Fistula

Allingham Ulcer

Perianal Fistula

Fistula In Ano

Anorectum Fistula
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14790 TNFAIP6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNFAIP6 RGD RGD:621359
Felis catus TNFAIP6 VGNC VGNC:66399
Mus musculus TNFAIP6 MGD MGI:1195266
Canis familiaris TNFAIP6 VGNC VGNC:47651
Bos taurus TNFAIP6 VGNC VGNC:36156
Macaca mulatta TNFAIP6 VGNC VGNC:78581