TNP2 - transition protein 2 Gene

Homo sapiens

Also known as TP2

Gene ID: 7142 | Gene type: protein coding

About TNP2

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,267,857-11,269,325 (from NCBI)

This gene has 2 transcripts (splice variants) and 66 orthologues. Restricted expression toward testis (RPKM 12.9).

Summary

Predicted to enable zinc ion binding activity. Predicted to be involved in positive regulation of protein processing; single fertilization; and spermatogenesis, exchange of chromosomal proteins. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in nucleus. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]

TNP2 Products(1)

mRNA	Protein	Name
NM_005425.5	NP_005416.1	nuclear transition protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31515488	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNP2 Protein Structure

TP2

0
100
138 a.a.

Protein Preferred Names

Protein Names

nuclear transition protein 2

TP-2

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Epididymo-Orchitis

Infertility

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Embryonal Testis Carcinoma

Testicular Embryonal Carcinoma	Embryonal Carcinoma Of Testis
Embryonal Carcinoma Of The Testis

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Oligospermia

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14858	TNP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNP2	RGD	RGD:3885
Mus musculus	TNP2	MGD	MGI:98785
Bos taurus	TNP2	VGNC	VGNC:36198
Felis catus	TNP2	VGNC	VGNC:66430
Macaca mulatta	TNP2	VGNC	VGNC:78608
Canis familiaris	TNP2	VGNC	VGNC:82301

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